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Designing universal T cell therapies: strategies to evade natural killer cells. [PDF]
Front ImmunolBushara O, Linette GP, Carreno BM.
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Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article. [PDF]
Hum Vaccin ImmunotherSoroush Fard A +5 more
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T cell decision-making decodes the dynamic antigenic landscape. [PDF]
Front ImmunolEizenberg-Magar I +3 more
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Uveal melanoma: A review of current treatment limitations and the emerging therapeutic potential of natural killer cells. [PDF]
J Invest DermatolNarayana RVL +3 more
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Antigen Receptors on B Lymphocytes
Annual Review of Immunology, 1992Recent studies on the structure of the B cell antigen receptor demonstrate that the membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer of two novel transmembrane proteins. The B cell antigen receptor is thus a multicomponent receptor complex whose structural features are similar to those of the ...
Michael Reth
exaly +3 more sources
Journal of the American Chemical Society, 2015
Chimeric antigen receptors (CARs) have shown great promise for the immunological treatment of cancer. Nevertheless, the need to genetically engineer a patient's T-cells has presented significant production and safety challenges. To address these issues, we have demonstrated that chemically self-assembled nanorings (CSANs) displaying single chain ...
Jingjing, Shen +2 more
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Chimeric antigen receptors (CARs) have shown great promise for the immunological treatment of cancer. Nevertheless, the need to genetically engineer a patient's T-cells has presented significant production and safety challenges. To address these issues, we have demonstrated that chemically self-assembled nanorings (CSANs) displaying single chain ...
Jingjing, Shen +2 more
openaire +2 more sources
Antigen-antigen receptor interactions
Current Opinion in Structural Biology, 1991Abstract The genetic basis of antigen receptor diversity is understood for both B and T cell systems. Structural aspects of five specific antibody-antigen interactions have also been described. During the past year, new data comparing the structures of liganded and unliganded antibodies have given support to the hypothesis that there exists a ...
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GTPases in antigen receptor signalling
Current Opinion in Immunology, 1998Immunological interest in small GTPases has focused for some years almost exclusively on the role of Ras in promoting lymphocyte activation and development. A new concept in this field is that GTPases are linked to multiple biochemical effector signalling pathways and are consequently able to regulate diverse cellular processes.
Henning, Stefan W, Cantrell, Doreen A
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Antigen receptor gene rearrangement
Current Opinion in Immunology, 1998Two specialized forms of site-directed double-strand (ds) DNA breakage and rejoining are part of the physiologic program of lymphocytes. One is recombination of the V, D and J gene sequences, termed V(D)J recombination, occurring during early B- and T-cell development, and the other is class-switch recombination occurring exclusively in mature B cells.
U, Grawunder, R B, West, M R, Lieber
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