Results 121 to 130 of about 27,078 (238)
Obesity Reviews, Volume 27, Issue 7, July 2026.ABSTRACT In a scenario with increasing cases of obesity and diabetes worldwide, branched‐chain amino acids (BCAA) metabolism has become an important factor in the understanding of these pathologies. More recently, its chronic high plasma levels have been postulated, alongside glucose, inflammatory factors, and other molecules, as an important ...
Bernardo Starling‐Soares +4 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 6, Page 1197-1212, June 2026.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 31, 2 June 2026.A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang +11 more
wiley +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang +10 more
wiley +1 more source
Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy
Aggregate, Volume 7, Issue 6, June 2026.Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao +5 more
wiley +1 more source
Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5. [PDF]
J Biol Chem, 2017 Corbisier J +4 more
europepmc +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan +5 more
wiley +1 more source