Results 121 to 130 of about 77,990 (218)

Development and characterization of chimeric antigen receptor macrophages for amyloid clearance. [PDF]

Front Immunol
Balachandran M, Foster JS, Hancock TJ, Martin EB, Jackson JW, Angell N, Wall JS.   +6 more
europepmc   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Ready or not, here they come: a practical guide to adoptive T-cell therapies for solid tumors for medical oncologists. [PDF]

Oncologist
Hoang T, Khan S, Sacher A.
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Involvement of the hospital pharmacist in securing the chimeric antigen receptor (CAR)-T cell circuit. [PDF]

Eur J Hosp Pharm
Bryla A, Lorent S, Vervacke A, Scolas G, Alexandre L.   +4 more
europepmc   +1 more source

Bacterial Biohybrids With Dual Magnet and Hypoxia Tropism for Ferroptosis Activation in Deep Tumor Regions

Exploration, EarlyView.
This study introduces a bacterial biohybrid (Ec@ZFOY) designed to target deep tumor regions using a combination of magnetic and hypoxia‐driven mechanisms for enhanced therapeutic delivery. By incorporating hypoxia‐targeted Escherichia coli and magnetic nanoparticles loaded with a HIF‐1α inhibitor, the biohybrid activates ferroptosis through reactive ...
Sijie Shao, Huilan Zhuang, Tingjie Bai, Xuemei Zeng, Angelo Homayoun All, Shuangqian Yan   +5 more
wiley   +1 more source

CAR-T and BiTE: new horizons in the treatment of rheumatic autoimmune diseases. [PDF]

Front Immunol
Li J, Guo Q, Li L, Wang J, Zhang L.
europepmc   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Engineering macrophages for effective and safe targeting of CD47 cancer cells in the tumor microenvironment. [PDF]

J Immunother Cancer
Andón FT, Rosales Sánchez A, Pensado-López A, García-Campelo R, Takimoto CH.   +4 more
europepmc   +1 more source

Autologous Extracellular Matrix‐Based Cell‐Free Therapy for Tissue Regeneration Through Trem2+ Macrophages Mediated Angiogenesis

Exploration, EarlyView.
ADF is prepared as a cell‐free bio‐membrane from autologous adipose ECM using simple physical techniques inspired by “papermaking”. It boasts superior properties and facilitates tissue regeneration through Trem2+ macrophages‐mediated angiogenesis. ADF can be stored long‐term for personalized medicine, offering insights into autologous ECM preservation ...
Mengmeng Hou, Nini Shi, Yajie Guo, Jiezhang Tang, Han Peng, Baoyan Liang, Yixuan Yu, Chenggang Yi, Huichen Li   +8 more
wiley   +1 more source