Results 271 to 280 of about 121,016 (287)

Chimeric Antigen Receptors for Cancer Immunotherapy

2016
The adoptive transfer of T lymphocytes expressing chimeric antigen receptors (CARs) has emerged as a promising treatment for various lymphoid and solid malignancies. Patients treated with CAR-T cells have achieved dramatic responses and in some cases, complete tumor eradication.
Claudia, Geldres, Barbara, Savoldo, Gianpietro, Dotti   +2 more
openaire   +2 more sources

Are All Chimeric Antigen Receptors Created Equal?

Journal of Clinical Oncology, 2015
In the report accompanying this article, Kochenderfer et al discuss the efficacy of autologous T cells expressing a CD19-specific chimeric antigen receptor (CAR) in patients with relapsed diffuse large B-cell lymphoma. Although previous reports have demonstrated significant antitumor activity in low-grade B-cell malignancies and B-cell acute ...
Jae H, Park, Renier J, Brentjens
openaire   +2 more sources

Chimeric antigen receptors

Nature Biotechnology, 2022
openaire   +2 more sources

Chimeric antigen receptor therapy meets mRNA technology

Trends in Biotechnology
Genetically engineered immune cells expressing chimeric antigen receptors (CARs) have emerged as a new game changer in cancer immunotherapy. The utility of CAR T cell therapy against hematological malignancies has been validated in clinical practice. Other CAR immune cells are currently under investigation to improve the potency of CAR therapy in solid
Jiacai Wu, Weigang Wu, Boping Zhou, Bin Li   +3 more
openaire   +2 more sources

Chimeric antigen receptor therapy in hematologic malignancies

JAAPA
ABSTRACT Chimeric antigen receptor (CAR) T-cell therapy has led to significant advances in the treatment of blood cancers such as leukemia, lymphoma, and multiple myeloma, and now shows promise for solid tumors. This type of immunotherapy can achieve high response rates in patients with hematologic malignancies, but carries serious adverse ...
Elizabeth, Brownlee, Melissa, Turley, Heather, Nations   +2 more
openaire   +2 more sources

Chimeric antigen receptors

Nature Biotechnology, 2020
openaire   +2 more sources

Chimeric antigen receptor Treg therapy in transplantation

Trends in Immunology
In the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR Tregs and how they may address important drawbacks of polyclonal Tregs and conventional immunosuppressants.
Siawosh K, Eskandari, Andrea, Daccache, Jamil R, Azzi   +2 more
openaire   +2 more sources

Chimeric Antigen Receptor Therapies

2020
Lisa Senzel, Tahmeena Ahmed, Yupo Ma
openaire   +1 more source

Chimeric Antigen Receptors

RCSB Protein Data Bank, 2017
openaire   +1 more source

Predicting chimeric antigen receptor apheresis process volume

Cytotherapy, 2023
Maximilian Lehmann, Halvard Bonig
openaire   +2 more sources