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The Other Face of Chimeric Antigen Receptors [PDF]
Molecular Therapy, 2014 The concept of chimeric antigen receptor (CAR) was pioneered in 1989 by Eshhar and colleagues with the specific goal of providing an alternative means by which T lymphocytes can engage antigens expressed by target cells.1 Until recently, the focus of CAR–T cell research has been on achieving effector function in T lymphocytes that can target cancer ...
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The application of CAR-T cell therapy in hematological malignancies: advantages and challenges
Acta Pharmaceutica Sinica B, 2018 Chimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR).
Zijun Zhao +4 more
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Conditionally Replicating Vectors Mobilize Chimeric Antigen Receptors against HIV
Molecular Therapy: Methods & Clinical Development, 2020 Human immunodeficiency virus (HIV) is an attractive target for chimeric antigen receptor (CAR) therapy. CAR T cells have proved remarkably potent in targeted killing of cancer cells, and we surmised that CAR T cells could prove useful in eradicating HIV ...
Ryan Z. Urak +8 more
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Chimeric Antigen Receptors Expand the Repertoire of Antigenic Macromolecules for Cellular Immunity
Cells, 2021 T-cell therapies have made significant improvements in cancer treatment over the last decade. One cellular therapy utilizing T-cells involves the use of a chimeric MHC-independent antigen-recognition receptor, typically referred to as a chimeric antigen ...
John T. Keane, Avery D. Posey
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Gene modification strategies for next-generation CAR T cells against solid cancers
Journal of Hematology & Oncology, 2020 Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies.
Yonggui Tian +3 more
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Nature Communications, 2023 Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo +10 more
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Frontiers in Immunology, 2019 Immune cell therapies based on the integration of synthetic antigen receptors comprise a powerful strategy for the treatment of diverse diseases, most notably T cells engineered to express chimeric antigen receptors (CAR) for targeted cancer therapy.
Theresa Pesch +9 more
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Cell Transplantation, 2022 Use of chimeric antigen receptors (CARs), as an immune cell therapy, has generated excellent clinical outcomes against hematologic tumors in recent years.
Xiaodi Zhang +7 more
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Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer.
PLoS ONE, 2013 Transfer of tumour antigen-specific receptors to T cells requires efficient delivery and integration of transgenes, and currently most clinical studies are using gamma retroviral or lentiviral systems.
Anne-Christine Field +9 more
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Chimeric Antigen Receptors Targeting Human Cytomegalovirus [PDF]
The Journal of Infectious Diseases, 2020 Abstract Human cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant morbidity in some vulnerable populations. Individualized adoptive transfer of ex vivo expanded CMV-specific CD8+ T cells has provided proof-of-concept that immunotherapy can be highly effective, but a chimeric antigen receptor (CAR) approach would ...
Ali, Ayub +9 more
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