Results 101 to 110 of about 186,066 (336)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Nuclear EGFR modulation of DNA repair [PDF]
, 2011 Overexpression of the epidermal growth factor receptor (EGFR) is associated with resistance to chemotherapy and radiotherapy. EGFR involvement, in repair of radiation-induced DNA damage, is mediated by association with the catalytic subunit of DNA ...
Liccardi, G.
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Cytoplasmic and Nuclear Estradiol Receptor in the Corpus Luteum of the Pseudopregnant Rabbit
Experimental Biology and Medicine, 1979 SummaryEstradiol binding activity has been measured in the rabbit corpus luteum on Days 2, 4, and 6 of pseudopregnancy. The results show that receptor activity is significantly greater on Day 4 than on Day 2 with continued increases on Day 6. In addition, the estradiol receptor activity is translocated into the nucleus within 30 min of injection of 100
openaire +2 more sources
Nuclear Translocation of the p75 Neurotrophin Receptor Cytoplasmic Domain in Response to Neurotrophin Binding [PDF]
The Journal of Neuroscience, 2005 The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by γ-secretase in response to the previous activation of α-secretase by phorbol esters. However, ligand-dependent release of p75ICDhas yet to be described. We show here that nerve growth factor can induce the release of p75ICDand facilitate its translocation to the ...
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.
PLoS ONE, 2014 In actively dividing eukaryotic cells, chromosome ends (telomeres) are subject to progressive shortening, unless they are maintained by the action of telomerase, a dedicated enzyme that adds DNA sequence repeats to chromosomal 3'end.
Cornelia Frohnert +4 more
doaj +1 more source
Neuroscience and Behavioral Physiology, 1985 Receptors for testosterone (T) in the preopticoanterior hypothalamus (PO) and in the arcuate nucleus and median eminence (ARC + ME) were examined in neonatally androgenized female and neonatally castrated male rats. As a result of neonatal castration of males, the concentration of cytoplasmic and nuclear receptors for T in the PO dropped to an ...
I V, Shishkina +2 more
openaire +3 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase
Mediators of Inflammation, 2019 A small group of only seven transcription factors known as STATs (signal transducer and activator of transcription) are considered to be canonical determinants of specific gene activation for a plethora of ligand/receptor systems. The activation of STATs
Howard M. Johnson +2 more
doaj +1 more source