Results 111 to 120 of about 186,066 (336)

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B

The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus.
Uwe Wolfrum, Felizitas F. Stiehler, Jacques S. Fritze   +2 more
core   +1 more source

Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: Thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors

, 2005
Drug-receptor binding thermodynamics has proved to be a valid tool for pharmacological and pharmaceutical characterization of molecular mechanisms of receptor-recognition phenomena.
DALPIAZ, Alessandro, SCATTURIN, Angelo, GILLI, Gastone, BOREA, Pier Andrea, GILLI, Paola, VARANI, Katia   +5 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB

iScience
Summary: Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse inducible T cell costimulator (mICOS) to ...
Annika De Sousa Linhares, Sumana Sharma, Peter Steinberger, Judith Leitner   +3 more
doaj   +1 more source

Glucocorticoid receptors in lung. Comparison between nonactivated and activated forms of the cytoplasmic glucocorticoid binding protein and their relationship to the nuclear binding protein of fetal rabbit lung.

Journal of Biological Chemistry, 1975
In the absence of salt the cytoplasmic glucocorticoid receptor of fetal rabbit lung sediments at 7 S while the nuclear receptor sediments at 4 S.
G. Giannopoulos
semanticscholar   +1 more source

NUCLEAR HORMONE RECEPTORS AS TARGETS FOR NEW DRUG DISCOVERY

, 1993
There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e ...
E. VEGETO, Donald P. McDonnell, Elisabetta Vegeto, D. MCDONNELL, M. GLEESON, Martin A. G. Gleeson   +5 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression.

PLoS ONE, 2016
The EGF-family of tyrosine-kinase receptors activates cytoplasmic pathways involved in cell proliferation, migration and differentiation in response to specific extracellular ligands.
Mahmoud El Maassarani, Alice Barbarin, Gaëlle Fromont, Ouafae Kaissi, Margot Lebbe, Brigitte Vannier, Ahmed Moussa, Paule Séité   +7 more
doaj   +1 more source

EVALUATION OF PROCEDURES FOR THE MEASUREMENT OF NUCLEAR AND CYTOPLASMIC STEROID-RECEPTORS IN HUMAN-PROSTATE

, 1979
EVALUATION OF PROCEDURES FOR THE MEASUREMENT OF NUCLEAR AND CYTOPLASMIC STEROID-RECEPTORS IN HUMAN ...
Craig Olsson (13064958), AM TRAISH (19230457), RE MULLER (19230460), HH WOTIZ (19230454)   +3 more
core  

A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

, 1993
Growth factors and cytokines act through cell surface receptors with different biochemical properties. Yet each type of receptor can elicit similar as well as distinct biological responses in target cells, suggesting that distinct classes of receptors ...
Gilman, M. Z., Darnell, J. E., Sadowski, H. B., Shuai, K.   +3 more
core   +1 more source