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Oncocytic Tumors in the Salivary Gland: Cytopathological, Pathological, and Molecular Features.
Acta CytolSkálová A +3 more
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Glucocorticoid receptor dimerization in the cytoplasm might be essential for nuclear localization
Biochemical and Biophysical Research Communications, 2021The glucocorticoid receptor (GR) plays an important role in steroid-dependent regulation of metabolism, development, and the immune response in humans. Although GR is known to be activated by the binding of glucocorticoid, the mechanism of action is poorly understood. We investigated dimerization of GR in the cytoplasm and nuclear trans-localization in
Su-Jun Lee +2 more
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Cytoplasmic-nuclear trafficking of steroid hormone receptors
Trends in Endocrinology & Metabolism, 1993The nuclear localization of most steroid hormone receptors reflects a dynamic process: the receptor constantly diffuses out of the nucleus and is reimported by an active mechanism. The outward movement from the nucleus of the receptors and of other nuclear proteins is also mediated by the nuclear localization signals.
Anne Guiochon-Mantel, Edwin Milgrom
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Nuclear and cytoplasmic estrogen receptors and progesterone receptors in breast cancer
European Journal of Cancer (1965), 1980The relationships of cytoplasmic estrogen receptors occupied and free nuclear estrogen receptors and cytoplasmic progesterone receptors measured in a series of 83 primary breast carcinoma were examined. 83% of the patients were postmenopausal (range in age 30-86 years; average age 59.7). Preparation of the cytosol and nuclear fractions were described
Ella Twaddle +9 more
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Cytoplasmic and Nuclear Estradiol and Progesterone Receptors in Human Endometrium*
The Journal of Clinical Endocrinology & Metabolism, 1978Estradiol and progesterone receptors have been characterized in normal human endometrial biopsy samples. The cytosol and nuclei were prepared from 150-250-mg samples, either processed immediately or kept in liquid nitrogen. The total concentration of estradiol-and progesterone-binding sites (available or occupied with endogenous hormone) were measured ...
Etienne-Emile Baulieu +3 more
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Binding of aldosterone to cytoplasmic and nuclear receptors of the rabbit kidney
American Journal of Physiology-Cell Physiology, 1981The binding characteristics of [3H]aldosterone ([3H]A) in the rabbit kidney were compared with those described in other species, and experimental conditions suitable for both the isolation of renal tubules and the retention of aldosterone receptors were examined.
Nicolette Farman +2 more
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Nuclear and cytoplasmic receptors for 1,25-dihydroxycholecalciferol in intestinal mucosa
Biochemical and Biophysical Research Communications, 1973The apparent hormonal form of cholecalciferol, 1,25-dihydroxycholecalciferol (1,25-(OH)2-CC), was incubated with intestinal mucosa homogenates and whole intestinal tissue, in vitro. After 40–70 min, 1,25-(OH)2-CC was specifically associated with the nuclear chromatin fraction.
Mark R. Haussler, P. F. Brumbaugh
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Cytoplasmic and Nuclear Cytokine Receptor Complexes
1997Much of our understanding on how hormones and cytokines transmit their message into the cell is based on the receptor activation at the plasma membrane. Many experimental in vitro models have established the paradigm for cytokine action based upon such activation of their cell surface receptor.
Gérard Morel +2 more
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