Results 211 to 220 of about 2,499,152 (288)

Local Regulation of Striatal Dopamine Release Shifts from Predominantly Cholinergic in Mice to GABAergic in Macaques. [PDF]

J Neurosci
Shin JH, Goldbach HC, Burke DA, Authement ME, Swanson ES, Bocarsly ME, Hernandez S, Kwon HB, Cerveny SE, Mehr JB, Plotnikova AS, Mohanty A, Cummins AC, Pelkey KA, McBain CJ, Khaliq ZM, Eldridge MAG, Averbeck BB, Alvarez VA.   +18 more
europepmc   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

ChemElectroChem, EarlyView.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský, Natália Košútová, Lenka Lorencová, Peter Kasák, Tomáš Bertók, Ján Tkáč   +5 more
wiley   +1 more source

α7-Nicotinic Acetylcholine Receptor and Mutated α-Synuclein Interact in Motor Behaviour and Nigrostriatal Dopamine-Findings With Potential Relevance for a Protective Effect of Cigarette Smoking and Parkinson's Disease. [PDF]

Eur J Neurosci
Pifl C, Wolf A, Elevado M, Scholze P.
europepmc   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

ChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia, Anna Maria Schito, Susanna Penco, Chiara Brullo, Marcus Baumann   +4 more
wiley   +1 more source

Fabrication and appraisal of axitinib loaded PEGylated spanlastics against MCF- 7 and OV- 2774 cell lines using molecular docking methods and in-vitro study. [PDF]

PLoS One
Zaki RM, Aldosari BN, Alkharashi LA, Alsalhi A, Afzal O, Alanazi BG, Alsunbul M, Bafail R, Abo El-Ela FI, Farouk HO.   +9 more
europepmc   +1 more source

Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D4R) Antagonist in vitro Tool compounds

ChemMedChem, EarlyView.
The work presents details of the efforts to design and characterize novel D4 inhibitors. A new 4,4‐difluoropiperidine ether series that confers improved potency and selectivity for D4 versus the other dopamine receptor subtypes is identified. Extensive structure‐activity relationship around this privileged group identifies the key structural changes to
Saeedeh Saeedi, Sumaiya Nahid, Anish K. Vadukoot, Corey R. Hopkins   +3 more
wiley   +1 more source

Combined Chronic Oral Methylphenidate and Fluoxetine Decreases D2R Levels in the Caudate Putamen and Nucleus Accumbens. [PDF]

Neurochem Res
Lagamjis G, Lu H, Roeder NM, Richardson BJ, Marion M, Quattrin T, Mastrandrea LD, Hadjiargyrou M, Komatsu DE, Thanos PK.   +9 more
europepmc   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Current insights and prospects for the pathogenesis and treatment of clinical manifestations associated with Down syndrome through neurotransmitter, inflammatory, and oxidative stress pathways. [PDF]

Front Pharmacol
Alasmari F, Ahmad A, Alsanea S, Hammad AM, Al-Qerem W.   +4 more
europepmc   +1 more source