Results 211 to 220 of about 2,526,995 (288)

Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex. [PDF]

NeuroSci
Kiknadze N, Narmania N, Sepashvili M, Barbakadze T, Zhuravliova E, Shetekauri T, Tkemaladze N, Oniani N, Mikeladze D.   +8 more
europepmc   +1 more source

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking.
Toshiki Iwabuchi, Takaharu Hirai, Naoko Umeda, Hideto Yogo, Yuuta Nishimiya, Yuuki Nishigaki, Masaru Watanabe, Hidenori Yamasue, Masatsugu Tsujii, Kenji J. Tsuchiya, Hideo Matsuzaki   +10 more
wiley   +1 more source

Mapping the cellular basis of species differences in oxytocin and dopamine receptor expression in the vole nucleus accumbens. [PDF]

Sci Rep
Loth MK, Schmidt JC, Gonzalez CA, Brusman LE, Sadino JM, Winther KE, Protter DSW, Donaldson ZR.   +7 more
europepmc   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications. [PDF]

Ann Med
Ren Q, Gu M, Fan X.
europepmc   +1 more source

Zebrafish: A Versatile and Powerful Model for Biomedical Research

BioEssays, EarlyView.
Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui, Hiba Siddiqui, Emna Riguene, Michail Nomikos   +3 more
wiley   +1 more source

SPLICEIT Fluorescent Sensor for Integrating Dopamine Release with Cellular Resolution. [PDF]

Angew Chem Int Ed Engl
Havens SM, Georgis B, Weng J, Rodriguez J, Rivett H, Alrawi S, Li P, Wang W.   +7 more
europepmc   +1 more source

The Allosteric Mechanism of G‐Protein‐Coupled Receptors is Induced Fit, Not Conformational Selection

BioEssays, EarlyView.
Allosteric signaling of G‐protein‐coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations upon binding of ligand agonists. Kinetic and structural data indicate that this population shift is induced by ligand binding to inactive receptor conformations prior to the conformational change from inactive to active.
Kazem Asadollahi, Paul R. Gooley, Thomas R. Weikl   +2 more
wiley   +1 more source

Dopamine receptor D1-mediated suppression of liver fibrosis <i>via</i> Hippo/Yes-associated protein 1 signaling in levodopa treatment. [PDF]

World J Gastroenterol
Wang HY, Qi MM, Zhang K, Zhu YZ, Zhang J.   +4 more
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source