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Dopamine receptor supersensitivity
Neuroscience & Biobehavioral Reviews, 1995Dopamine (DA) receptor supersensitivity refers to the phenomenon of an enhanced physiological, behavioral or biochemical response to a DA agonist. Literature related to ontogenetic aspects of this process was reviewed. Neonatal 6-hydroxydopamine (6-OHDA) destruction of rat brain DA neurons produces overt sensitization to D1 agonist-induced oral ...
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Dopamine receptors and hypertension
Current Hypertension Reports, 2008Dopamine plays an important role in regulating renal function and blood pressure. Dopamine synthesis and dopamine receptor subtypes have been shown in the kidney. Dopamine acts via cell surface receptors coupled to G proteins; the receptors are classified via pharmacologic and molecular cloning studies into two families, D1-like and D2-like.
Anees Ahmad Banday +1 more
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Dopamine receptor pharmacology
2007Publisher Summary This chapter discusses the basic aspects of dopamine receptor pharmacology and biology. The dopamine receptors, members of the heptahelical G-protein-coupled receptor (GPCR) superfamily, are divided into two subfamilies: the ‘D1-like’ and ‘D2-like’.
Richard B. Mailman, Xuemei Huang
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Annals of Clinical Psychiatry, 1994
This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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1981
Publisher Summary This chapter discusses the characterization of dopamine receptor subtypes, and characteristics of radioligand-binding to dopamine receptors, and its application for neurology and psychiatry. Recently, the function of dopamine in the brain has been elevated from that of a precursor for the neurotransmitter norepinephrine to a ...
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Publisher Summary This chapter discusses the characterization of dopamine receptor subtypes, and characteristics of radioligand-binding to dopamine receptors, and its application for neurology and psychiatry. Recently, the function of dopamine in the brain has been elevated from that of a precursor for the neurotransmitter norepinephrine to a ...
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Comparative and General Pharmacology, 1971
Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Receptors | Dopamine Receptors
Encyclopedia of Biological Chemistry III, 2021semanticscholar +1 more source
Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy
European Journal of Pharmacology: Molecular Pharmacology, 1990Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds like apomorphine, CY 208-243, 6,7-ADTN and 3-PPP were either D2-selective or did
Jens Aas Jansen, Peter H. Andersen
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Schizophrenia and dopamine receptors
European Neuropsychopharmacology, 2013Schizophrenia patients are behaviorally supersensitive to dopamine-like drugs such as amphetamine or methylphenidate, meaning that patients respond to such drugs with increased psychotic symptoms, as compared to control subjects. A basis of such supersensitivity may be an increased pre-synaptic release of dopamine or a post-synaptic elevation of D2 ...
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Dopamine receptors and the dopamine hypothesis of schizophrenia
Synapse, 1987AbstractThe discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The Parkinsonian effects caused by neuroleptics suggested that dopamine transmission may be disrupted by these drugs.
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