Results 251 to 260 of about 241,431 (287)
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Dopamine receptor pharmacology
2007Publisher Summary This chapter discusses the basic aspects of dopamine receptor pharmacology and biology. The dopamine receptors, members of the heptahelical G-protein-coupled receptor (GPCR) superfamily, are divided into two subfamilies: the ‘D1-like’ and ‘D2-like’.
Richard B, Mailman, Xuemei, Huang
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Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy
European Journal of Pharmacology: Molecular Pharmacology, 1990Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds like apomorphine, CY 208-243, 6,7-ADTN and 3-PPP were either D2-selective or did
P H, Andersen, J A, Jansen
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American Journal of Hypertension, 1990
Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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2001
Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
X, Huang +4 more
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Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
X, Huang +4 more
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Dopamine receptor supersensitivity
Neuroscience & Biobehavioral Reviews, 1995Dopamine (DA) receptor supersensitivity refers to the phenomenon of an enhanced physiological, behavioral or biochemical response to a DA agonist. Literature related to ontogenetic aspects of this process was reviewed. Neonatal 6-hydroxydopamine (6-OHDA) destruction of rat brain DA neurons produces overt sensitization to D1 agonist-induced oral ...
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Dopamine Receptors And Hypertension
Acta Clinica Belgica, 1988Dopamine receptors and ...
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2002
Abstract Dopamine is one of the major neurotransmitters in the central nervous system. Central dopaminergic systems participate in a number of important physiological functions. These systems control voluntary as well as involuntary motor movements, execution of learned motor programs, and regulate the secretion of prolactin and ...
Lucien Gazi, Philip G Strange
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Abstract Dopamine is one of the major neurotransmitters in the central nervous system. Central dopaminergic systems participate in a number of important physiological functions. These systems control voluntary as well as involuntary motor movements, execution of learned motor programs, and regulate the secretion of prolactin and ...
Lucien Gazi, Philip G Strange
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Multiple receptors for dopamine
Nature, 1979Pharmacological and biochemical criteria can be used to separate those dopamine receptors which are linked to the enzyme adenylyl cyclase and those which are not.
J W, Kebabian, D B, Calne
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Dopamine Receptor and Hypertension
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2005Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and/or impaired dopamine receptor function have been reported in hypertension.
Chunyu, Zeng +3 more
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Dopamine receptors and hypertension
Current Hypertension Reports, 2008Dopamine plays an important role in regulating renal function and blood pressure. Dopamine synthesis and dopamine receptor subtypes have been shown in the kidney. Dopamine acts via cell surface receptors coupled to G proteins; the receptors are classified via pharmacologic and molecular cloning studies into two families, D1-like and D2-like.
Anees Ahmad, Banday +1 more
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