Results 151 to 160 of about 27,293 (207)

Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy

European Journal of Pharmacology: Molecular Pharmacology, 1990
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds like apomorphine, CY 208-243, 6,7-ADTN and 3-PPP were either D2-selective or did
P H, Andersen, J A, Jansen
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D1 dopamine receptors

2001
Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
X, Huang, C P, Lawler, M M, Lewis, D E, Nichols, R B, Mailman   +4 more
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Postmortem stability of dopamine D1 receptor mRNA and D1 receptors

Molecular Brain Research, 1993
The effects of postmortem interval on dopamine D1 mRNA and D1 receptors were assessed in rat striatum under conditions simulating the handling of human brain tissue at 0, 6, 12, and 24 h postmortem. The amount of D1 mRNA was measured by both in situ hybridization film and emulsion autoradiography with [35S]dATP-labeled oligonucleotide probes.
J H, Gilmore, C P, Lawler, A M, Eaton, R B, Mailman   +3 more
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Photoaffinity labeling of dopamine D1 receptors

Biochemistry, 1988
A high-affinity radioiodinated D1 receptor photoaffinity probe, (+/-)-7-[125I]iodo-8-hydroxy-3-methyl-1-(4-azidophenyl)-2,3,4,5-tetra hyd ro- 1H-3-benzazepine ([125I]IMAB), has been synthesized and characterized. In the absence of light, [125I]IMAB bound in a saturable and reversible manner to sites in canine brain striatal membranes with high affinity
H B, Niznik, K R, Jarvie, N H, Bzowej, P, Seeman, R K, Garlick, J J, Miller, N, Baindur, J L, Neumeyer   +7 more
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Dopamine D1 receptors facilitate transmitter release

Nature, 1993
A physiological role for the dopamine D1 receptor has been difficult to define, particularly because of its complex pre- and postsynaptic localization in brain areas such as the striatum. In the midbrain, however, D1 receptors are selectively localized to the terminals of GABA (gamma-aminobutyric acid)-containing afferents.
D L, Cameron, J T, Williams
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Cocaine increases ryanodine receptors via dopamine D1 receptors

Synapse, 2011
AbstractFor review there are little available data on regulatory mechanisms of ryanodine receptor (RyR) expression with cocaine treatment, though methamphetamine was reported to up‐regulate RyRs in mouse brain. This study attempted to investigate regulatory mechanisms of RyR expression using the cerebral cortical neurons in primary culture ...
Kazuhiro, Kurokawa, Koji, Mizuno, Masahiro, Shibasaki, Emi, Kiyokage, Kazunori, Toida, Seito, Ohkuma   +5 more
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The selective dopamine D1 receptor agonist SKF81297 modulates NMDA receptor currents independently of D1 receptors

Neuropharmacology, 2022
Dopamine D1 receptor (D1R) agonists are frequently used to study the role of D1Rs in neurotransmission and behaviour. They have been repeatedly shown to modulate glutamatergic NMDAR currents in the prefrontal cortex (PFC), giving rise to the idea that D1R activation tunes glutamatergic networks by regulating NMDAR activity.
Maya O. Nesbit, Anping Chai, Peter Axerio-Cilies, Anthony G. Phillips, Yu Tian Wang, Katharina Held   +5 more
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Dopamine D1-receptor immunolocalization in goldfish retina

The Journal of Comparative Neurology, 1999
Dopamine, a neuromodulator in the vertebrate retina, is involved in numerous functions related to light adaptation. However, unlike in mammals, localization of retinal D1-dopamine receptors in nonmammalian vertebrates has been hampered due to a lack of antisera. To address this problem, an antiserum against the 18 C-terminal amino acids of the goldfish
C, Mora-Ferrer, S, Yazulla, K M, Studholme, M, Haak-Frendscho   +3 more
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Highlights of D1 dopamine receptor antagonist research

Neurochemistry International, 1992
SCH 39166 is now undergoing clinical trials in schizophrenics as a selective D1 dopamine receptor antagonist. It differs from SCH 23390, the prototype D1 receptor antagonist, by having reduced affinity for serotonin receptors and a longer duration of action in primates, as measured in the squirrel monkey conditioned avoidance paradigm.
A, Barnett, R D, McQuade, C, Tedford
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