Results 171 to 180 of about 27,293 (207)

Location and molecular cloning of D1 dopamine receptor

Neurochemistry International, 1992
Recently, our laboratory has purified the D1 dopamine receptor 6600 fold to near homogeneity from digitonin solubilized rat striatal membranes using sequential affinity, ion exchange, lectin, and size exclusion chromatographies. The resulting receptor preparations still retained ligand binding activity (-11,000 pmol [3H]SCH 23390 bound per mg/protein ...
J A, Gingrich, A, Dearry, P, Falardeau, M D, Bates, R T, Fremeau, M G, Caron   +5 more
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Dopamine D1 receptor modulation of pilocarpine-induced convulsions

Neuroscience, 1990
The contribution of dopaminergic mechanisms to the generalization of epileptic activity was studied in rats given pilocarpine after pretreatment with selective dopamine agonists. At the dose of 200 mg/kg, pilocarpine produced limbic stereotypes but not convulsions or seizure-related brain damage.
BARONE, Paolo, Parashos SA, Palma V, Marin C, Campanella G, Chase T.N.   +5 more
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Neuroleptics differentially modulate central dopamine D1-receptor binding

NeuroReport, 1995
The effect of the classical neuroleptic, fluphenazine, on dopamine D1-receptor binding was examined in different regions of the basal ganglia. Whereas exposure to fluphenazine for 18 months reduced [125I]SCH-23982 binding to D1-receptors in the caudate putamen, nucleus accumbens and olfactory tubercle, binding in the entopeduncular nucleus was enhanced
A E, Johnson, H, Coirini, L, Källström, L M, Gunne, F A, Wiesel   +4 more
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The Dopamine D1 Receptor: Biochemical and Behavioral Aspects

1986
Research on the role of dopamine (DA) in the control of behavior was initiated with the studies by Randrup and colleagues in the early 60’es (e.g., Randrup et al., 1965). However, the direct study of DA receptors began with the discovery in 1972 of DA sensitive adenylate cyclase in rat striatum (Kebabian et al., 1972).
P H, Andersen, E B, Nielsen
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Dopamine receptor subtypes: beyond the D1/D2 classification

Trends in Pharmacological Sciences, 1990
The D1/D2 dopamine receptor classification is widely accepted. However, intense investigative efforts over the last several years using pharmacological, biochemical and behavioral approaches have produced results that are increasingly difficult to reconcile with the existence of only two dopamine receptor subtypes.
P H, Andersen, J A, Gingrich, M D, Bates, A, Dearry, P, Falardeau, S E, Senogles, M G, Caron   +6 more
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Signal Transduction by Dopamine D1 Receptors

2002
In vertebrates the D1 family of dopamine receptors comprises at least three members, coded by different genes: D1a (or D1), D1b (or D5), and D1c/d (Vernier et al. 1995). However, only D1 and D5 have been identified in mammals. These receptors are characterized by their high degree of sequence identity and their common ability to interact with Gs-like ...
J.-A. Girault, P. Greengard
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Role of dopamine D1 receptors in cocaine lethality

Pharmacology Biochemistry and Behavior, 1995
One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment with the newly developed full-efficacy D1 agonist dihydrexidine (DHX) and a dose of (60 mg/kg) cocaine ...
M D, Schechter, S M, Meehan
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Parkinson's disease and D1 dopamine receptors.

Current opinion in investigational drugs (London, England : 2000), 2002
This article reviews the role of the D1-like dopamine receptors in Parkinson's disease (PD), an idea supported by the location of D1 receptors in key aspects of basal ganglia circuitry. The initial disappointing results with available partial D1 agonists have been replaced by optimism as newer full D1 agonists have been shown to be the only class of ...
R, Mailman, X, Huang, D E, Nichols
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The Pathophysiological Functions Mediated by D1 Dopamine Receptors

1986
The administration of the D1 DA receptor antagonist SCH 23390 produces catalepsy in rat, and this behavior can be abolished by pretreatment with selective D2 DA receptor agonists. The administration of mixed D1/D2 DA agonists, but not of selective D2 DA agonists, produces SMB behavior in monkeys with surgical unilateral VMT lesions of the brain stem ...
M, Goldstein, S, Kuga, Y, Shimizu, E, Meller   +3 more
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Dopamine D1/D2 Receptor Interaction

Psychiatry and Clinical Neurosciences, 1991
M, Sasa, A, Akaike, Y, Ohno, M, Hara, S, Takaori   +4 more
openaire   +2 more sources