Results 51 to 60 of about 27,293 (207)

Development of Novel Tavapadon Analogs as Dual-targeted Partial Agonists Based on the Dopamine D₁/D₅ Receptors

Pharmaceutical Fronts
Tavapadon is a potent, selective G protein-biased partial agonist for the dopamine D1/D5 receptors, with positive experimental results in phase 3 trials for the treatment of Parkinson's disease (PD).
Fan Shi, Jian Jia, Zhijing Hu, Yini Yang, Peng Xie, Zehong Wan, Guan Wang   +6 more
doaj   +1 more source

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

Nature Communications, 2018
D1-like dopamine receptors are coupled to Golf proteins in the dorsal striatum but Gs in cortical and other areas. Here, the authors demonstrate selective agonism of Gs-coupled versus Golf-coupled D1 receptors.
Hideaki Yano, Ning-Sheng Cai, Min Xu, Ravi Kumar Verma, William Rea, Alexander F. Hoffman, Lei Shi, Jonathan A. Javitch, Antonello Bonci, Sergi Ferré   +9 more
doaj   +1 more source

Neuronal Excitation in the Ventral Tegmental Area Modulates the Micturition Reflex Mediated via the Dopamine D1 and D2 Receptors in Rats

Journal of Pharmacological Sciences, 2003
Involvement of the dopamine D1 and D2 receptors in the ventral tegmental area (VTA) in the micturition reflex was investigated using female Sprague Dawley rats under urethane anesthesia.
Kiyoshi Hashimoto, Tatsuya Oyama, Takahide Sugiyama, Young-Chol Park, Takashi Kurita   +4 more
doaj   +1 more source

Evaluation of D1 and D2 dopamine receptor segregation in the developing striatum using BAC transgenic mice. [PDF]

PLoS ONE, 2013
The striatum is predominantly composed of medium spiny neurons (MSNs) that send their axons along two parallel pathways known as the direct and indirect pathways.
Dominic Thibault, Fabien Loustalot, Guillaume M Fortin, Marie-Josée Bourque, Louis-Éric Trudeau   +4 more
doaj   +1 more source

Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation

Movement Disorders, EarlyView.
Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, Christoph Schröder, Jens C. Schwamborn   +11 more
wiley   +1 more source

Dopamine D1-Like Receptors Suppress the Proliferation of Macrophages Induced by Ox-LDL

Cellular Physiology and Biochemistry, 2016
Background/Aims: Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, a key physiological process which leads to atherosclerosis.
Yonggang Yao, Di Yang, Yu Han, Wei Wang, Na Wang, Jian Yang, Chunyu Zeng   +6 more
doaj   +1 more source

Dopamine depolarizes podocytes via a D1-like receptor [PDF]

Nephrology Dialysis Transplantation, 1999
Dopamine influences glomerular haemodynamics and dopamine receptors have been demonstrated in the glomerulus, but little is known about the cellular effects of dopamine in glomerular cells. The aim of this study was to investigate the influence of dopamine on the cellular functions of podocytes.The effect of dopamine on membrane voltage was ...
Bek, Martin J., Fischer, Karl-Georg, Greiber, Stefan, Hupfer, Charlotte, Mundel, Peter, Pavenstädt, Hermann   +5 more
openaire   +3 more sources

G Protein–Coupled Receptors in Olfactory Signaling and Related Disorders: Mechanisms and Therapeutic Implications

Sensory Neuroscience, EarlyView.
This schematic highlights GPCRs as the central hub of olfactory signaling in health and disease. The central GPCR shows odorant activation and downstream pathways. Surrounding quadrants illustrate four GPCR‐mediated themes: odor perception and adaptation, mucosal immunity and regeneration, memory consolidation via neural circuits, and GPCR‐related ...
Zishuo Guo, Hongjie Du, Fanyu Yuan, Yuhan Dong, Fangyuan Zhu, Jian Liu, Chengzhilin Li, Xu Guo, Zhaoze Yang, Wenwen Qi, Ming Xia, Chengcheng Liu   +11 more
wiley   +1 more source

Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression. [PDF]

J Neurochem
Stress during adolescence or adulthood affects the ability of the prefrontal cortex (PFC) to adaptively regulate stress. Maladaptive adult stress leads to PFC hypofunction and a hypodopaminergic state in the medial, affect‐related ventral tegmental area (VTA), resulting in amotivation.
Uliana DL, Grace AA.
europepmc   +2 more sources

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source