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Main interactions of dopamine and risperidone with the dopamine D2 receptor
Physical Chemistry Chemical Physics, 2021A comparison between dopamine and risperidone shows that weak non-covalent interactions are relevant in understanding the antipsychotic drug mechanism.
Ana Martínez +4 more
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The Physiological Role of Dopamine D2 Receptors
1997Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi, Adolfo +5 more
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Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
Biochemical and Biophysical Research Communications, 2013Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D2R) and neurotensin 1 (NTS1R) receptor-receptor interactions in the dorsal and ventral striatum indicating a potential role of these receptor-receptor interactions in Parkinson's disease and schizophrenia.
Borroto Escuela D. O. +10 more
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1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Olivier Civelli +4 more
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Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Olivier Civelli +4 more
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D2 dopamine receptor gene and alcoholism
Journal of Psychiatric Research, 1993An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Stéphane Amadéo +12 more
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Synthesis and processing of D2 dopamine receptors
Biochemistry, 1993Dopamine receptors belong to a superfamily of neurotransmitter receptors that are functionally coupled to guanine nucleotide binding proteins. In this study, we have used Chinese hamster ovary (CHO) cells stably transfected with the rat D2L receptor, in conjunction with specific anti-peptide antibodies that we have developed, in order to visualize this
C, David +4 more
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The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors
Neuroscience, 1994Dopamine D2 receptors were inactivated by N-ethoxycarbonyl-2-ethoxy-1,2,-dihydroxy-quinoline (EEDQ) (6 mg/kg i.p.). The reduction in dopamine receptors was monitored by quantitative receptor autoradiography using [125I]iodosulpiride or [3H]raclopride as radioligands.
S O, Ogren, L, Rosén, K, Fuxe
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Dopamine D2 Receptors in Signal Transduction and Behavior
Critical Reviews™ in Neurobiology, 1997The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis ...
Picetti +5 more
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Aspects of the structure of the D2 dopamine receptor
Trends in Neurosciences, 1990Significant new information on the D2 dopamine receptor has recently become available from a combination of protein chemical and molecular genetic analyses. Molecular genetic studies have shown the receptor to be a member of the family of receptors that are linked to G proteins and that have structures predicted to contain seven transmembrane domains ...
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