Results 241 to 250 of about 150,460 (322)

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia

Molecular Psychiatry, 2002
S. Kapur, P. Seeman
semanticscholar   +1 more source

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

British Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.
Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link, Jakob Sture Madsen, David E. Gloriam, Hans Bräuner‐Osborne, Alexander S. Hauser   +4 more
wiley   +1 more source

Structural Aspects of Arylpiperazines as Aminergic GPCR Ligands. [PDF]

Molecules
Bartyzel A, Cristóvão B, Kaczor AA.
europepmc   +1 more source

Positive Effects of Caffeine Therapy in a Girl with PDE2A‐Related Paroxysmal Dyskinesia

Movement Disorders Clinical Practice, Volume 12, Issue 7, Page 1014-1016, July 2025.
Katerina Bernardi, Moritz Thiel, Anne Koy   +2 more
wiley   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Electroconvulsive therapy for depression and oral dyskinesia in a patient who developed parkinsonism induced by valbenazine. [PDF]

PCN Rep
Mori Y, Suzuki Y, Sato A, Shishido R, Kobayashi Y, Fukuchi Y, Inada S, Iwasaki Y, Sato R, Takada K, Morita N, Miura I.   +11 more
europepmc   +1 more source

Relevance of G protein‐coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation

British Journal of Pharmacology, Volume 182, Issue 14, Page 3211-3224, July 2025.
Abstract G protein‐coupled receptors (GPCRs) are one of the major drug targets. In recent years, computational drug design for GPCRs has mainly focused on static structures obtained through X‐ray crystallography, cryogenic electron microscopy (cryo‐EM) or in silico modelling as a starting point for virtual screening campaigns. However, GPCRs are highly
Marta Lopez‐Balastegui, Tomasz Maciej Stepniewski, Małgorzata M. Kogut‐Günthel, Antonella Di Pizio, Mette Marie Rosenkilde, Jiafei Mao, Jana Selent   +6 more
wiley   +1 more source

A Bridge Too Far? Towards Medical Therapy for Clinically Nonfunctioning Pituitary Tumors. [PDF]

Int J Mol Sci
Mogar N, Zhang D, Heaney AP.
europepmc   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source