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Dopamine D2 Receptor and Tourette's Syndrome
Archives of Neurology, 1995I was pleased to see the study by Gelernter et al 1 concerning the role of the dopamine D 2 receptor ( DRD2 ) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric ...
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Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides
Biochemical and Biophysical Research Communications, 1996Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets ...
G Y, Ng +6 more
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Olfactory receptor neurons express D2 dopamine receptors
The Journal of Comparative Neurology, 1999The role of the dopamine (DA) in the olfactory bulb (OB) was explored by determining which of the potential target cells express dopamine receptors (DARs). Previously, it was reported that D2-like DAR (D2, D3, and D4 subtypes) radioligand binding is restricted to the outer layers of the OB.
N L, Koster +6 more
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Modulation of dopamine metabolism in the retina via dopamine D2 receptors
Brain Research, 1990When rats are placed in a lighted environment from the dark retinal DOPAC increases. There is no significant change of retinal dopamine (DA) under either lighting condition. Blockade of aromatic L-amino acid decarboxylase results in a more rapid accumulation of DOPA in the retina of animals in the light than in the dark implying that DA synthesis and ...
M, Hadjiconstantinou +3 more
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Dopamine-D2-receptor-agonists/dopamine-D2-receptor-partial-agonists
Reactions Weekly, 2022openaire +1 more source
Isolation and characterization of D2-dopamine receptors
Biochemical Society Transactions, 1985Strange, PG +3 more
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D2 Dopamine Receptors and Schizophrenia
1991The dopamine hypothesis of schizophrenia postulates that an elevation of the D2 dopamine receptor density could be part of the pathophysiology of the disease. To assess this question, in vivo studies of the D2 receptors have been performed in drug-free schizophrenics using positron emission tomography.
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Purification of the D2 dopamine receptor
Trends in Biochemical Sciences, 1989openaire +2 more sources
Separation of dopamine D1 and D2 receptors
European Journal of Pharmacology, 1985A, Dumbrille-Ross, H, Niznik, P, Seeman
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