Results 121 to 130 of about 6,763,423 (338)
Drug receptors: A long engagement [PDF]
Nature, 2002 The term 'receptor' is generally reserved for a molecule that acts as a biological signal transducer, usually for hormones or neurotransmitters.
openaire +3 more sources
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands
BMC Bioinformatics, 2018 Background The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases.
Johannes M Freudenberg +3 more
doaj +1 more source
Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence [PDF]
, 2017 We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation.
Bossert, Jennifer M. +6 more
core +2 more sources
The mathematics of drug-receptor interactions [PDF]
Journal of Pharmacy and Pharmacology, 1966 Abstract MOST pharmacological observations support the hypothesis that drugs produce their effects by interacting in a specific way with some component of the living cell. This component, which is likely to be either an enzyme or a site on a cell membrane, is called the receptor.
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The Concise Guide to PHARMACOLOGY 2015/16: G protein‐coupled receptors
British Journal of Pharmacology, 2015 The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org
Stephen P. H. Alexander +10 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs
International Journal of Nanomedicine, 2014 Antonella Accardo,1 Luigi Aloj,2 Michela Aurilio,2 Giancarlo Morelli,1 Diego Tesauro11Centro interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Department of Pharmacy and Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle ...
Accardo A +4 more
doaj
Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
Oncology Reviews, 2011 This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans.
Julie Scholler, Dominique Leveque
doaj +1 more source
Neural signatures of cognitive flexibility and reward sensitivity following nicotinic receptor stimulation in dependent smokers : a randomized trial [PDF]
, 2017 IMPORTANCE Withdrawal from nicotine is an important contributor to smoking relapse. Understanding how reward-based decision making is affected by abstinence and by pharmacotherapies such as nicotine replacement therapy and varenicline tartrate may aid ...
Aronson, Sarah E. +5 more
core +2 more sources