Results 201 to 210 of about 6,763,423 (338)

Expanding Horizons of Buprenorphine: A Comprehensive Narrative Review of Its Pharmacological Properties and Clinical Applications in Chronic Pain. [PDF]

Pain Ther
Fornasari D, Cuomo A.
europepmc   +1 more source

Drug receptors and drug design

Japanese Journal of Pharmacology, 1995
openaire   +2 more sources

Muscarinic acetylcholine receptors: novel opportunities for drug development

Nature reviews. Drug discovery, 2014
A. Kruse, B. Kobilka, D. Gautam, P. Sexton, A. Christopoulos, J. Wess   +5 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

EC₅₀ images reveal reproducible spatial variation in drug affinity across single- and repeat-dose occupancy studies. [PDF]

J Cereb Blood Flow Metab
Ibrahimy A, Kim SJ, Schmidt ME, Slifstein M, Mannaert E, Andrews RD, Matthews DC, Constantinescu CC, Searle GE, Gunn RN, Rabiner EA, Morris ED.   +11 more
europepmc   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Lysergic Acid Diethylamide (LSD) and the Heart: Exploring the Potential Impacts of LSD on Cardiovascular Function. [PDF]

Cureus
Suleria A, Verma S, Arya K, Stoltzfus MT, Gupta I, Singh B, Shaik T.   +6 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Planar-electroporated cell biosensor for investigating potential therapeutic effects of ectopic bitter receptors. [PDF]

Microsyst Nanoeng
Chen C, Wu J, Qin C, Qiu Y, Jiang N, Wang Q, Liu M, Jiang D, Yuan Q, Wei X, Zhuang L, Wang P.   +11 more
europepmc   +1 more source