Results 211 to 220 of about 725,377 (269)
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Current Protocols in Pharmacology, 2006
AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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Advances in receptor chromatography for drug discovery and drug–receptor interaction studies
Drug Discovery Today, 2023Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug-receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site ...
Jia Fu +4 more
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Gastrointestinal Drug Receptors
Journal of Clinical Gastroenterology, 1983Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes.
T F, Burks, J J, Galligan, F, Porreca
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Drug Receptors and their Function
Nature, 1971There have been various theories about the way in which drugs exert their effects. If recent progress in the isolation of receptors continues, it should soon be possible to look directly at the interaction between drugs and tissues.
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Challenges for receptor theory as a tool for drug and drug receptor classification
Trends in Pharmacological Sciences, 1989Increased understanding in the field of receptor pharmacology, born of the sophisticated techniques now available to us, has confounded rather than simplified the problem of receptor classification. The International Union of Pharmacology (IUPHAR) is currently sponsoring a Receptor Nomenclature Committee whose aims are to recommend a rational system of
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1978
It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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The emergence of the drug receptor theory
Nature Reviews Drug Discovery, 2002Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most ...
Andreas-Holger, Maehle +2 more
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Drug interactions at GABAA receptors
Progress in Neurobiology, 2002Neurotransmitter receptor systems have been the focus of intensive pharmacological research for more than 20 years for basic and applied scientific reasons, but only recently has there been a better understanding of their key features. One of these systems includes the type A receptor for the gamma-aminobutyric acid (GABA), which forms an integral ...
Esa R, Korpi +2 more
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Immunophilin Receptors for Immunosuppressive Drugs
Therapeutic Drug Monitoring, 1993The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP 12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature is reviewed on some possible mechanisms
S J, Soldin +4 more
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