Results 221 to 230 of about 725,377 (269)
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Interaction of muscarinic drugs with their receptor
General Pharmacology: The Vascular System, 1985Interaction of muscarinic drugs with their receptor was studied in the logitudinal muscle of guinea pig ileum. The pD2-value, the index for agonistic activity of a partial agonist was practically equal to its pA2-value, the index for competitive antagonistic activity and to its pKA-value which was a negative logarithm of a dissociation constant (KA ...
I, Takayanagi, K, Okumura, K, Koike
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Angiotensin receptor blockers and drug–drug interactions
Expert Opinion on Drug Safety, 2005The pharmacokinetic characteristics of the angiotensin receptor blocker class are such that significant drug-drug interactions are unlikely. Moreover, this drug class is devoid of relevant class-specific side effects. These features provide some of the basis for the excellent tolerance of drugs in this class.
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Serotonergic Receptors and Drugs in Hypertension
Pharmacology & Toxicology, 1992Abstract:The possible role of 5‐hydroxytryptamine (5HT) and 5HT‐receptors in hypertension, already suggested by Page in 1954, has been subject to a renaissance of interest owing to the development of antihypertensive drugs which interact with 5HT‐receptors. These drugs, like ketanserin, urapidil and flesinoxan are used as tools to study the role of 5HT
P A, van Zwieten +2 more
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The classification of drugs and drug receptors in isolated tissues.
Pharmacological Reviews, 1984The major premise of this review is that isolated more effective therapeutic agents for man. In this contissues can be used efıctively to obtain information text, the bias of this paper will be pharmacological in about drugs and drug receptors which transcends species that receptors will be used to gain information about and function. This information,
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Photoproteins as models of drug receptors
Life Sciences, 1978Abstract The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.
J R, Blinks +3 more
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Drugs, 1990
This paper reviews the theoretical concepts and methods utilised with isolated tissues to characterise drugs and drug receptors. Specifically the impact, on the in vitro measurement of agonist affinity and relative efficacy, of the idea that receptors bind to transduction proteins in the lipid bilayer of the cell membrane is discussed.
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This paper reviews the theoretical concepts and methods utilised with isolated tissues to characterise drugs and drug receptors. Specifically the impact, on the in vitro measurement of agonist affinity and relative efficacy, of the idea that receptors bind to transduction proteins in the lipid bilayer of the cell membrane is discussed.
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Drug and Neurotransmitter Receptors in the Brain
Science, 1984Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism.
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Glycine Receptor Drug Discovery
2017Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W. +3 more
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Receptors, Neurotransmitters and Drug Responses
New England Journal of Medicine, 1979ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine.
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Nuclear receptor drug discovery
Current Opinion in Chemical Biology, 2008Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
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