Results 201 to 210 of about 725,377 (269)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Attenuation of cue-induced heroin-seeking by the atypical antidepressant mirtazapine. [PDF]

Drug Alcohol Depend Rep
Persons AL, Napier TC.
europepmc   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review). [PDF]

Oncol Rep
Li H, Song S, Wang L, Liu Q.
europepmc   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Analyzing the Chemical Space of Opioid Receptor Agonists and Antagonists: Insights from Computational Models. [PDF]

ACS Omega
Yu T, Anuwongcharoen N, Wang ZJ, Piacham T.   +3 more
europepmc   +1 more source

Nature-Inspired Alternatives to PEG for Next-Generation Long-Circulating Nanocarriers. [PDF]

Int J Nanomedicine
Jan N, Rejili M.
europepmc   +1 more source

Human Serum Albumin as a Prodrug Carrier for Tumor Therapy: Mechanisms, Applications, and Future Perspectives. [PDF]

Pharmaceutics
Shang Y, Wang S, Yan Y, Tian E, She L, Ma Z.   +5 more
europepmc   +1 more source

Short- and Long-Acting Psychedelics: Structure-Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics. [PDF]

ACS Chem Neurosci
Bhat A, Zolali E, Sakib MA, Rahimian M, McMahon LR, German N, Obeng S.   +6 more
europepmc   +1 more source

Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear. [PDF]

Brain
Yamamuro K, Ikehara M, Noriyama Y, Okuda M, Okumura K, Matsuoka K, Kashida N, Ishida R, Takeda T, Toritsuka M, Ochi T, Miyasaka T, Tai Y, Tatsumi K, Hattori T, Tanaka T, Saito Y, Iwata N, Makinodan M.   +18 more
europepmc   +1 more source