Results 281 to 290 of about 6,763,423 (338)

Trans-Cannabitriol as a Dual Inhibition of MPOX Adhesion Receptors L1R and E8L: An In Silico Perspective. [PDF]

Bioinform Biol Insights
Abbou H, Zegrari R, Gaouzi Z, Belyamani L, Bourais I, Eljaoudi R.   +5 more
europepmc   +1 more source

Extracellular vesicle-hitchhiking nanoliposomes for cancer-associated fibroblast phenotype modulation impede metastasis progression. [PDF]

Sci Adv
Chen F, He Z, Guo R, Li M, Li J, Wang Y, He X, Tian Z, Ling X, Xiong L, Bai W, Li M, He Q.   +12 more
europepmc   +1 more source

Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle. [PDF]

World J Gastroenterol
Smirnova OV, Sinyakov A, Kasparov EV.
europepmc   +1 more source

Receptor-enriched analysis of functional connectivity (REACT) for understanding cannabinoid neuropsychopharmacology

Shatalina E, Ertl N, Petrilli K, Ofori S, Borisova A, Mokrysz C, Curran HV, Lawn W, Freeman TP, Howes O, Wall MB.   +10 more
europepmc   +1 more source

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Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development.

Annual Review of Pharmacology and Toxicology, 2020
Electron cryo-microscopy (cryo-EM) has revolutionized structure determination of membrane proteins and holds great potential for structure-based drug discovery.
J. García-Nafría, C. Tate
semanticscholar   +1 more source

Advances in receptor chromatography for drug discovery and drug–receptor interaction studies

Drug Discovery Today, 2023
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug-receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site ...
Jia Fu, Wei Qin, Lu-Qi Cao, Zhe-Sheng Chen, Hui-Ling Cao   +4 more
openaire   +2 more sources

Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.

Journal of Medicinal Chemistry, 2018
G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at allosteric sites provide the potential for differential selectivity and ...
Shaoyong Lu, Jian Zhang
semanticscholar   +1 more source

Chemokines and their receptors: drug targets in immunity and inflammation.

Annual Review of Pharmacology and Toxicology, 2008
The chemokine system coordinates leukocyte migration in immunity and inflammation and is implicated in the pathogenesis of many human diseases. Although several successful strategies have been identified to develop drugs targeting chemokines and their ...
A. Viola, A. Luster
semanticscholar   +1 more source

Gastrointestinal Drug Receptors

Journal of Clinical Gastroenterology, 1983
Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes.
Thomas F. Burks, James J. Galligan, Frank Porreca   +2 more
openaire   +3 more sources