Results 51 to 60 of about 6,519,345 (216)

Historeceptomic fingerprints for drug-like compounds

Frontiers in Physiology, 2015
Most drugs exert their beneficial and adverse effects through their combined action on several different molecular targets (polypharmacology). The true molecular fingerprint of the direct action of a drug has two components: the ensemble of all the ...
Evgeny eShmelkov, Arsen eGrigoryan, James eSwetnam, Junyang eXin, Doreen eTivon, Sergey eShmelkov, Sergey eShmelkov, Timothy eCardozo   +7 more
doaj   +1 more source

Screening of medicinal plants for possible herb-drug interactions through modulating nuclear receptors, drug-metabolizing enzymes and transporters. [PDF]

J Ethnopharmacol, 2023
Husain I, Dale OR, Martin K, Gurley BJ, Adams SJ, Avula B, Chittiboyina AG, Khan IA, Khan SI.   +8 more
europepmc   +1 more source

STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE

Nature, 2018
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion.
Sheng Wang, T. Che, A. Levit, B. Shoichet, Daniel Wacker, B. Roth   +5 more
semanticscholar   +1 more source

Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs

International Journal of Nanomedicine, 2014
Antonella Accardo,1 Luigi Aloj,2 Michela Aurilio,2 Giancarlo Morelli,1 Diego Tesauro11Centro interuniversitario di Ricerca sui Peptidi Bioattivi (CIRPeB), Department of Pharmacy and Istituto di Biostrutture e Bioimmagini - Consiglio Nazionale delle ...
Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D   +4 more
doaj  

Uncovering new disease indications for G-protein coupled receptors and their endogenous ligands

BMC Bioinformatics, 2018
Background The Open Targets Platform integrates different data sources in order to facilitate identification of potential therapeutic drug targets to treat human diseases.
Johannes M Freudenberg, Ian Dunham, Philippe Sanseau, Deepak K Rajpal   +3 more
doaj   +1 more source

Application of hyaluronic acid as carriers in drug delivery

Drug Delivery, 2018
Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells ...
G. Huang, Hualiang Huang
semanticscholar   +1 more source

mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy

Frontiers in Bioscience-Landmark
Glutamate is an important neurotransmitter in the mammalian brain. Among the receptors that glutamate interacts with is metabotropic glutamate (mGlu) receptor 2, a Gαi/o-coupled receptor.
Li-Min Mao, Elizabeth Puthumana, John Q. Wang   +2 more
doaj   +1 more source

Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans

Oncology Reviews, 2011
This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans.
Julie Scholler, Dominique Leveque
doaj   +1 more source

Biased Receptor Signaling in Drug Discovery

Pharmacological Reviews, 2019
A great deal of experimental evidence suggests that ligands can stabilize different receptor active states that go on to interact with cellular signaling proteins to form a range of different complexes in varying quantities.
T. Kenakin
semanticscholar   +1 more source

Genetic inference of on-target and off-target side-effects of antipsychotic medications.

PLoS Genetics
It is often difficult to ascertain whether patient-reported side-effects are caused by a drug, and if so, through which mechanism. Adverse side-effects are the primary cause of antipsychotic drug discontinuation rather than poor efficacy.
Andrew R Elmore, Aws Sadik, Lavinia Paternoster, Golam M Khandaker, Tom R Gaunt, Gibran Hemani   +5 more
doaj   +1 more source