Results 61 to 70 of about 6,519,345 (216)

Progress in structure-based drug development targeting chemokine receptors

Frontiers in Pharmacology
As a critical subfamily of G protein-coupled receptors (GPCRs), chemokine receptors (CCRs) play pivotal regulatory roles in immune cell migration, inflammatory modulation, tissue regeneration, and tumor microenvironment (TME) remodeling.
Jin Wang, Chen Qu, Peng Xiao, Sijin Liu, Jin-Peng Sun, Yu-Qi Ping   +5 more
doaj   +1 more source

Rational Drug Design and Synthesis of Molecules Targeting the Angiotensin II Type 1 and Type 2 Receptors

Molecules, 2015
The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an array of biological processes that regulate human health. Aberrant function of these receptors triggers pathophysiological responses that can ultimately lead to death.
Tahsin F. Kellici, Andreas G. Tzakos, Thomas Mavromoustakos   +2 more
doaj   +1 more source

Solubilization and Display of G Protein-Coupled Receptors on Beads for Real-Time Fluorescence and Flow Cytometric Analysis

BioTechniques, 2000
G protein-coupled receptors (GPCR) and cellular signaling elements are prime targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities for these elements can play significant roles in basic research and drug discovery.
L.A. Sklar, J. Vilven, E. Lynam, D. Neldon, T.A. Bennett, E. Prossnitz   +5 more
doaj   +1 more source

ROR nuclear receptors: structures, related diseases, and drug discovery

Acta Pharmacologica Sinica, 2014
Nuclear receptors (NRs) are ligand-regulated transcription factors that regulate metabolism, development and immunity. The NR superfamily is one of the major classes of drug targets for human diseases. Retinoic acid receptor-related orphan receptor (ROR)
Yan Zhang, Xiao-yu Luo, Dong-hai Wu, Yong Xu   +3 more
semanticscholar   +1 more source

In vitro screening of major neurotransmitter systems possibly involved in the mechanism of action of antibodies to S100 protein in released-active form

Neuropsychiatric Disease and Treatment, 2015
Evgeniy A Gorbunov, Irina A Ertuzun, Evgeniya V Kachaeva, Sergey A Tarasov, Oleg I EpsteinOOO “NPF “MATERIA MEDICA HOLDING”, Moscow, Russian FederationAbstract: Experimentally and clinically, it was shown that released-active form of ...
Gorbunov EA, Ertuzun IA, Kachaeva EV, Tarasov SA, Epstein OI   +4 more
doaj  

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

eLife
Despite major successes with inhibitory receptor blockade in cancer, the identification of novel inhibitory receptors as putative drug targets is needed due to lack of durable responses, therapy resistance, and side effects.
Akashdip Singh, Alberto Miranda Bedate, Helen J von Richthofen, Saskia V Vijver, Michiel van der Vlist, Raphael Kuhn, Alexander Yermanos, Jürgen J Kuball, Can Kesmir, M Ines Pascoal Ramos, Linde Meyaard   +10 more
doaj   +1 more source

Drugs and receptors

Continuing Education in Anaesthesia Critical Care & Pain, 2004
There are four principle protein targets with which drugs can interact: enzymes (e.g. neostigmine and acetyl cholinesterase), membrane carriers (e.g. tricyclic antidepressants and catecholamine uptake-1), ion channels (e.g. nimodipine and voltage-gated Ca2+ channels) and receptors.
openaire   +1 more source

Dosing optimization of rituximab for primary membranous nephropathy by population pharmacokinetic and pharmacodynamic study

Frontiers in Pharmacology
Primary membranous nephropathy (PMN) is the most common cause for adult nephrotic syndrome. Rituximab has demonstrated promising clinical efficacy by random controlled trials and the off-label use is widely adopted in PMN. However, the standard dosage is
Hao Liang, Hao Liang, Zhenling Deng, Shu Niu, Weijie Kong, Weijie Kong, Yang Liu, Song Wang, Haiyan Li, Yue Wang, Danxia Zheng, Dongyang Liu, Dongyang Liu, Dongyang Liu   +13 more
doaj   +1 more source

Neuropeptides and Neuropeptide Receptors: Drug Targets, and Peptide and Non‐Peptide Ligands: a Tribute to Prof. Dieter Seebach

Chemistry and Biodiversity, 2012
D. Hoyer, T. Bártfai
semanticscholar   +1 more source

Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions

Nature Communications
Current strategies for active targeting in the brain are entirely based on the effective interaction of the ligand with the orthosteric sites of specific receptors on the blood-brain barrier (BBB), which is highly susceptible to various ...
Kaicheng Tang, Zhongjie Tang, Miaomiao Niu, Zuyin Kuang, Weiwei Xue, Xinyu Wang, Xinlong Liu, Yang Yu, Seongdong Jeong, Yifan Ma, Annette Wu, Betty Y. S. Kim, Wen Jiang, Zhaogang Yang, Chong Li   +14 more
doaj   +1 more source