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Endothelin Receptor Antagonist
2017Endothelin (ET)-1, a peptide mainly produced by vascular endothelial cells, has potent and long-lasting vasoconstrictive effect. In addition, ET-1 has been shown to induce a variety of biological effects including cell proliferation, inflammation, and fibrosis.
Noriaki Emoto, Noriaki Emoto
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1998
Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
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Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
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Endothelin Receptors and Ligands
1999The discovery of endothelin led to a huge body of research, much of it aimed at elucidating the receptors through which the endothelins act. Clearly, it was reasoned, the ability to antagonise the effects of such a powerful vasoconstrictor could be of potential benefit in a number of disease states.
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Cloning and expression of a cDNA encoding an endothelin receptor
Nature, 1990H. Arai +4 more
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Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
Nature, 1990T. Sakurai +6 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2009
Waldiceu A. Verri Jr +9 more
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Waldiceu A. Verri Jr +9 more
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