Results 111 to 120 of about 33,352 (233)

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

The Immuno‐Cardiovascular Storm of Pre‐Eclampsia: Cytokine‐Mediated Endothelial Injury, Thrombosis, and Maternal Cardiovascular Instability

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Placental ischemia in pre‐eclampsia initiates cytokine‐driven endothelial dysfunction, angiogenic imbalance, oxidative stress, and thromboinflammation. Elevated TNF‐α, IL‐6, IL‐17, sFlt‐1, and complement activation promote vasoconstriction, thrombosis, and cardiovascular instability.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Targeting Peptidergic Systems for Melanoma Treatment. [PDF]

Cancers (Basel)
Sánchez ML, Mehboob R, Coveñas R.
europepmc   +1 more source

A Review of Breath Sensing for Disease Monitoring and Diagnosis: Breathomics, Artificial Intelligence, and Nanomaterials for the Future of Medicine

Advanced Sensor Research, Volume 5, Issue 7, July 2026.
Breathomics is established as a non‐invasive diagnostic strategy by combining volatile organic compound biomarkers, nanomaterial‐based sensor arrays, and AI‐driven classification. Key diseases, sensing materials, and analytical challenges are critically compared, revealing how portable, data‐enabled breath platforms are moving toward clinically useful ...
Anesu Nyabadza, Mayur Makhesana, Suman Chatterjee, Dermot Brabazon   +3 more
wiley   +1 more source

Natural History of Chronic Kidney Disease in Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 7, Page 1456-1477, July 2026.
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley   +1 more source

Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis. [PDF]

World J Exp Med
Thalassinos E, Notas G, Xidakis C, Drygiannakis I, Sfakianaki O, Tsomidis I, Kouroumalis E.   +6 more
europepmc   +1 more source

The Impact of Collection Protocol on the Yield and Purity of Mesenchymal Stem Cell‐Derived Extracellular Vesicles Isolated From Serum‐Free Media

Biotechnology Journal, Volume 21, Issue 7, July 2026.
Graphical Abstract and Lay Summary Mesenchymal stem cells (MSCs) were cultured in standard, ultracentrifuged (UC), or starvation serum‐free media to evaluate how medium influences extracellular vesicle (EV) yield and purity. Culture in UC medium improved EV purity but reduced yield.
Jolene Phelps, Sara Hassanpour Tamrin, Neil A. Duncan, Arindom Sen   +3 more
wiley   +1 more source

Progress in mechanistic and clinical translational research of endothelin A receptor antagonists in the treatment of diabetic kidney disease: a narrative review. [PDF]

Front Endocrinol (Lausanne)
Li M, Xie C, Qiu Y, Li X, Han G, Ma N, Wang G.   +6 more
europepmc   +1 more source