Results 11 to 20 of about 63,448 (267)

Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy [PDF]

Respiratory Research, 2017
Background: Patients with congenital diaphragmatic hernia (CDH) have structural and functional different pulmonary vessels, leading to pulmonary hypertension.
Buscop-Van Kempen, M. (Marjon), Mous, D.S. (Daphne), Rottier, R.J. (Robbert), Tibboel, D. (Dick), Wijnen, R.M.H. (René)   +4 more
core   +3 more sources

Structural basis of peptide recognition and activation of endothelin receptors

Nature Communications, 2023
Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.
Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang   +12 more
doaj   +1 more source

Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. [PDF]

PLoS ONE, 2017
BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role.
Gry Freja Skovsted, Lars Schack Kruse, Lukas Adrian Berchtold, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson   +5 more
doaj   +1 more source

Endothelins as mediators in the modulation of cardiac performance [PDF]

Praxis Medica, 2014
The role of endothelin in cardiovascular physiology and pathophysiology has been undeniable ever since its discovery. Endothelins in the heart are important for the development, growth and remodeling, as well as for the control of contractility and ...
Smiljić Sonja, Radović D., Nestorović V., Milanović Z., Biševac B.   +4 more
doaj   +1 more source

High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

Frontiers in Cardiovascular Medicine, 2021
Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic valve disease in diabetes.
Sergiu Cecoltan, Letitia Ciortan, Razvan D. Macarie, Mihaela Vadana, Andreea C. Mihaila, Monica Tucureanu, Mihaela-Loredana Vlad, Ionel Droc, Mihaela Gherghiceanu, Agneta Simionescu, Agneta Simionescu, Dan Teodor Simionescu, Dan Teodor Simionescu, Elena Butoi, Ileana Manduteanu   +14 more
doaj   +1 more source

Endothelin and the Cardiovascular System: The Long Journey and Where We Are Going

Biology, 2022
Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous ...
Andreas Haryono, Risa Ramadhiani, Gusty Rizky Teguh Ryanto, Noriaki Emoto   +3 more
doaj   +1 more source

Endothelin in health and disease

Biomolecules & Biomedicine, 2004
Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3).
Emina Nakaš-Ićindić, Asija Začiragić, Almira Hadžović, Nešina Avdagić   +3 more
doaj   +1 more source

Cerebrospinal fluid from patients with subarachnoid haemorrhage and vasospasm enhances endothelin contraction in rat cerebral arteries.

PLoS ONE, 2015
IntroductionPrevious studies have suggested that cerebrospinal fluid from patients with subarachnoid hemorrhage (SAH) leads to pronounced vasoconstriction in isolated arteries.
Barbara Assenzio, Erica L Martin, Edgaras Stankevicius, Federica Civiletti, Marco Fontanella, Marco Fontanella, Riccardo Boccaletti, Maurizio Berardino, AnnaTeresa Mazzeo, Alessandro Ducati, Ulf Simonsen, Luciana Mascia   +11 more
doaj   +1 more source

Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. [PDF]

PLoS ONE, 2011
BACKGROUND: Endothelin-1 is a potent endogenous vasoconstrictor that contributes to renal microcirculatory impairment during endotoxemia and sepsis. Here we investigated if the renal circulatory and metabolic effects of endothelin during endotoxemia are ...
Johan Fenhammar, Andreas Andersson, Jakob Forestier, Eddie Weitzberg, Alf Sollevi, Hans Hjelmqvist, Robert Frithiof   +6 more
doaj   +1 more source

The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease

Haematologica, 2017
Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease.
Bérengère Koehl, Pierre Nivoit, Wassim El Nemer, Olivia Lenoir, Patricia Hermand, Catia Pereira, Valentine Brousse, Léa Guyonnet, Giulia Ghinatti, Malika Benkerrou, Yves Colin, Caroline Le Van Kim, Pierre-Louis Tharaux   +12 more
doaj   +1 more source