Results 191 to 200 of about 33,352 (233)

Endothelins and their receptors in embryo implantation

Journal of Cellular Biochemistry, 2019
AbstractAs a critical stage of pregnancy, the implantation of blastocysts into the endometrium is a progressive, excessively regulated local tissue remodeling step involving a complex sequence of genetic and cellular interplay executed within an optimal time frame. For better understanding the causes of infertility and, more importantly, for developing
Aynaz Mihanfar, Aydin Raei Sadigh, Amir Fattahi, Zeinab Latifi, Mahsa Hasanzadeh‐Moghadam, Mahrokh Samadi, Laya Farzadi, Kobra Hamdi, Aliyeh Ghasemzadeh, Hamid Reza Nejabati, Mohammad Nouri   +10 more
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Endothelin, endothelin receptors, and endothelin antagonists.

Current opinion in nephrology and hypertension, 1995
Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor, ETC. In vascular smooth muscle cells, endothelin causes profound contraction and also has proliferative effects, mainly through activation of ETA but also through ETB ...
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Desensitization of Human Endothelin A Receptor

Journal of Cardiovascular Pharmacology, 1993
The response of G-protein-coupled receptors is modulated by homologous desensitization. Because endothelin A receptor (ETA) plays a part in vasoconstriction, the extent of desensitization and resensitization of endothelin responsiveness was studied.
C, Cyr, R M, Kris
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Characterization of Endothelin Receptor Subtypes

Journal of Cardiovascular Pharmacology, 1991
Scatchard-plot analysis of [125I]ET-1 and [125I]ET-3 binding to rat lung membranes exhibited almost the same Kd values whereas the concentration of the binding sites of ET-1 is approximately four times higher than that of ET-3. This result suggests the presence of at least two distinct subtypes of ET receptors: an ET-1-specific type and an ET-3 ...
H, Miyazaki, M, Kondoh, H, Watanabe, T, Shibata, Y, Masuda, K, Murakami   +5 more
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Effect of castration on endothelin receptors

Clinical Science, 2002
Endothelin (ET) plays a pivotal role in the pathogenesis of cell growth disorders such as cancer. Atrasentan (ABT-627), a selective antagonist for the ET receptor A (ETA), has shown benefit in controlling disease progression in men with hormone refractory prostate cancer who have undergone aggressive hormone ablation therapy.
Robert J, Padley, Douglas B, Dixon, J Ruth, Wu-Wong   +2 more
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Endothelin Receptor Antagonists - An Overview

Current Medicinal Chemistry, 2002
In thirteen years since the appearance of Endothelin (ET) on the international scene, possibility of its involvement in a variety of diseases has attracted the attention of medicinal chemists in search of novel therapeutics for various cardiovascular diseases (CVDs).
Falguni, Dasgupta, Ashis K, Mukherjee, N, Gangadhar   +2 more
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Internalization of Type-A Endothelin Receptor

Journal of Cardiovascular Pharmacology, 2000
Endothelins (ETs) are 21 amino acid peptides which bind to ET(A)- and ET(B)-receptors to evoke diverse physiological responses. This report studies the internalization of ET(A)-receptor in Chinese hamster ovary (CHO) cells which were stably transfected with ET(A)-receptor cDNA.
J, Wang, W J, Chiou, G D, Gagne, J R, Wu-Wong   +3 more
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Endothelins and sarafotoxins: Receptor heterogeneity

International Journal of Biochemistry, 1994
1. Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of 21-amino-acid peptides comprising at least eight isoforms. 2. ET exerts multiple pharmacological effects through its receptors. 3. This review summarizes the observations and findings pointing to the existence of receptor subtypes and leading to their identification. 4.
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[Molecular biology of endothelins and endothelin receptors].

Nihon rinsho. Japanese journal of clinical medicine, 1993
Endothelin (ET) was initially identified as a potent vasoconstrictor peptide with 21 amino-acid residues, produced by cultured porcine aortic endothelial cells. Cloning of the ET genes revealed the existence of three isopeptides, ET-1, ET-2 and ET-3, which are widely distributed in a variety of tissues and possess wide variety of pharmacological ...
H, Arai, K, Hosoda, G, Shirakami, T, Yoshimasa, K, Nakao   +4 more
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Endothelin receptors

Trends in Pharmacological Sciences, 1993
S, Hirose, H, Hagiwara
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