Results 41 to 50 of about 2,352,473 (305)
Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent
R. Waldsee+3 more
doaj +1 more source
Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1.
Irina V. Kibalina, Namzhil N. Tsybikov
doaj +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam+4 more
core +1 more source
Portopulmonary hypertension practice patterns after liver transplantation
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose+3 more
wiley +1 more source
Endothelin-1 Role in Human Eye: A Review
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Serena Salvatore, Enzo Maria Vingolo
doaj +1 more source
Repurposing of the Drug Tezosentan for Cancer Therapy
Tezosentan is a vasodilator drug that was originally developed to treat pulmonary arterial hypertension. It acts by inhibiting endothelin (ET) receptors, which are overexpressed in many types of cancer cells. Endothelin-1 (ET1) is a substance produced by
Eduarda Ribeiro, Nuno Vale
doaj +1 more source
Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]
Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A.+3 more
core +1 more source
Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ...
F.Z. Gonçalves+9 more
doaj +1 more source
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed+62 more
core +2 more sources
Endothelin receptors: what's new and what do we need to know?
Receptors are at the heart of how a molecule transmits a signal to a cell. Two receptor classes for endothelin (ET) are recognized, the ET(A) and ET(B) receptors.
S. Watts
semanticscholar +1 more source