Results 51 to 60 of about 63,448 (267)

Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ET_A receptors

BMC Neuroscience, 2011
Background Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS ...
Cao Yong-Xiao, Zhang Yaping, Xu Cang-Bao, Cao Lei, Edvinsson Lars   +4 more
doaj   +1 more source

Contribution of Piezo2 to endothelium-dependent pain. [PDF]

, 2015
BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver, Ferrari, Luiz F, Green, Paul, Levine, Jon D   +3 more
core   +2 more sources

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration

Frontiers in Physiology, 2020
BackgroundWhile chemerin has been shown to increase proliferation and migration of systemic vascular smooth muscle cells (SMCs) contributing therefore to the development of hypertension, this remains to be clarified for the pulmonary circulation ...
Aliénor Hanthazi, Pascale Jespers, Grégory Vegh, Christine Dubois, Géraldine Hubesch, Jean-Yves Springael, Laurence Dewachter, Kathleen Mc Entee   +7 more
doaj   +1 more source

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Ahmmed, Albert, Albert, Albert, Albert, Albert, Albert, Albert, Anthony P. Albert, Boualleque, Clapham, Davenport, Davenport, Drummond, Fukami, Hamill, Hardie, Helliwell, Inoue, Ivey, Kawanabe, Kinlay, Kwon, Large, Lemonnier, Liu, Miwa, Nakanishi, Nilius, Otsuguro, Peppiatt-Wildman, Rohacs, Saleh, Saleh, Saleh, Schiffrin, Sohag N. Saleh, Sugawara, Sumner, Trebak, Tseng, Vanhaesebroeck, Voets, Wang, William A. Large   +44 more
core   +2 more sources

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation

BMC Cardiovascular Disorders, 2020
Background Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury.
Enyong Su, Linwei Zhao, Xiaohang Yang, Binbin Zhu, Yahui Liu, Wen Zhao, Xianpei Wang, Datun Qi, Lijie Zhu, Chuanyu Gao   +9 more
doaj   +1 more source

Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]

, 2016
Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam, Lopes, Rheure Alves, Montezano, Augusto C., Rios, Francisco, Touyz, Rhian   +4 more
core   +1 more source