Results 71 to 80 of about 33,352 (233)

Aprocetentin (Tryvio): A breakthrough in treating Resistant Hypertension

Journal of the Pakistan Medical Association
According to a scientific statement from the American Heart Association, Resistant hypertension is defined as blood pressure that remains above target levels (i.e., less than 140/90 mmHg, or less than 130/80 mmHg in patients with diabetes or chronic ...
Zara Babar, Areesha Babar
doaj   +1 more source

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source

Treatment of IgA nephropathy; focus on reducing proteinuria by endothelin A receptor antagonists [PDF]

Journal of Nephropathology
IgA nephropathy (IgAN) is the most frequent primary glomerulonephritis throughout world and a leading cause of chronic renal failure across with end-stage kidney failure.
Elham Ahmadipour, Hamid Nasri
doaj   +1 more source

Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells

Endocrine Regulations, 2019
Objective. The aim of the present investigation was to study the effect of hypoxia on the expression of genes encoding endothelin-1 (EDN1) and its cognate receptors (EDNRA and EDNRB) as well as endothelin converting enzyme 1 (ECE1) in U87 glioma cells in
Minchenko Dmytro O., Tsymbal Daria O., Riabovol Olena O., Viletska Yuliia M., Lahanovska Yuliia O., Sliusar Myroslava Y., Bezrodnyi Borys H., Minchenko Oleksandr H.   +7 more
doaj   +1 more source

Protein kinase C inhibition attenuates vascular ET_B receptor upregulation and decreases brain damage after cerebral ischemia in rat

BMC Neuroscience, 2007
Background Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ...
Vikman Petter, Stenman Emelie, Henriksson Marie, Edvinsson Lars   +3 more
doaj   +1 more source

Intraoperative Cardiac Events During Pediatric Cardiac Magnetic Resonance Imaging Under Anesthesia: A Retrospective Cohort Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Children with congenital heart disease (CHD) frequently undergo cardiac magnetic resonance imaging (MRI) under anesthesia. Although these procedures lack surgical stimulus, patients remain physiologically vulnerable, and the incidence of perioperative cardiovascular instability in this setting is poorly defined.
Theodora Wingert, Justine Liang, Kelly Feldman, Amelie Delaporte, Christine Nguyen‐Buckley, Tristan Grogan, Alexandre Joosten, John Paul Finn, Ihab Ayad   +8 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

CLINICAL CASE OF COMBINATION THERAPY INCLUDING AMBRIZENTAN IN THE PATIENT WITH SEVERE IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION

Евразийский Кардиологический Журнал, 2017
Idiopathic pulmonary hypertension (IPAH) is a rare cardiovascular disease of unknown etiology, but the most common form of pulmonary arterial hypertension, defined as mean pulmonary arterial pressure >25 mmHg and pulmonary vascular resistance >3 ...
G. A. Movsisyan, O. A. Arkhipova, I. Z. Korobkova, Yu. G. Matchin, M. A. Saidova, T. V. Martynyuk, I. Ye. Chazova   +6 more
doaj   +1 more source

A review of sitaxsentan sodium in patients with pulmonary arterial hypertension

Vascular Health and Risk Management, 2007
Aaron B WaxmanDepartment of Internal Medicine, Pulmonary Critical Care Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USAAbstract: Pulmonary arterial hypertension (PAH) is a life threatening, progressive condition which ...
Aaron B Waxman
doaj  

Biomarkers to predict outcomes in diabetic foot ulcers

VIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro, Kellie Fortune, Eimear Daly, Luca McCann, Merhan Soltan, Seamus Sreenan, Fabio Quondamatteo   +6 more
wiley   +1 more source