Results 191 to 200 of about 127,469 (270)

The Immunomodulatory Role of Estrogen in Malaria: A Review of Sex Differences and Therapeutic Implications. [PDF]

Immun Inflamm Dis
Wu Y, Chen YC, Liu FF, Li K.
europepmc   +1 more source

Chlorogenic Acid: An In‐Depth Review of Its Effectiveness in Cancer Treatment

Cancer Nexus, EarlyView.
ABSTRACT Cancer remains a formidable global health challenge. Owing to the unsatisfactory curative effects and severe side effects, it is urgent to explore safer and more effective therapeutic alternatives and drugs. Chlorogenic acid (CGA), a natural polyphenol, has emerged as a promising candidate for cancer therapy due to its multiple functions and ...
Bin Wang, Na Yin, Xinrui Liu, Yang Bai, Yue Cao, Ziqian Wang, Shiqi Bai, Shaopeng Zhang, Wanying Li, Yinghui Wang   +9 more
wiley   +1 more source

Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis. [PDF]

Cell Discov
Li T, Wang G, Zhao H, Liu F, Deng Z, Chen D, Zhou X, Cao Y, Fu W, Zhang H, Yang J.   +10 more
europepmc   +1 more source

Inorganic Nanoparticles in Reproduction Biology: Opportunities and Challenges

ChemPlusChem, Accepted Article.
The development of inorganic metal and metal oxide nanoparticles (MNPs) has attracted significant attention in biomedical and biotechnological fields. An emerging field in this context is the use of MNPs in reproduction biology. Here, we review the development of MNPs in the field of reproduction by focusing on their interactions with highly delicate ...
Stephan Barcikowski, Sangita Kundu, Christoph Rehbock, Wilfried A. Kues   +3 more
wiley   +1 more source

Osteoclast Activation and Inflammatory Bone Diseases: Focusing on Receptors in Osteoclasts. [PDF]

J Inflamm Res
Zhao W, Li J, Su T, Wang C, Fu Y, Li C, Hua P, Liang X, Zhu Y, Cui H.   +9 more
europepmc   +1 more source

Use of Real‐World Claims Data to Assess the Prevalence of Concomitant Medications to Inform Drug–Drug Interaction Risk in Target Patient Populations

Clinical Pharmacology &Therapeutics, EarlyView.
A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang, Logan Brooks, Denise M. Boudreau, Pascal Chanu, Amita Joshi, Bianca Vora, Rui Zhu   +6 more
wiley   +1 more source

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Clinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler, Caíque Manóchio, Bruno Miwa, Guilherme Belfort‐Almeida, Lucas Faria‐Costa, Cesar Sanchez, Carlos Padilla, Omar Caceres, Eduardo Tarazona‐Santos, Heinner Guio, Timothy D. O'Connor, Fernanda Rodrigues‐Soares   +11 more
wiley   +1 more source

Steroid receptors and coregulators: Dissemination of sex differences and emerging technologies. [PDF]

J Biol Chem
Pauss SN, Bates EA, Martinez GJ, Bates ZT, Kipp ZA, Gipson CD, Hinds TD.   +6 more
europepmc   +1 more source

Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
As single‐arm trials (SATs) are increasingly used in pharmaceutical research, the validity of such study designs needs to be critically assessed. We characterize the feasibility of supplementing SATs with real‐world data (RWD)‐derived external control arms by determining the proportion of SATs on breast cancer and amyotrophic lateral sclerosis (ALS ...
Martin Russek, Jonas Peltner, Britta Haenisch   +2 more
wiley   +1 more source

Tryptophan and Its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain-Gut-Microbiome Axis: A Focus on Sex Differences. [PDF]

Cells
Xu M, Zhou EY, Shi H.
europepmc   +1 more source