Results 31 to 40 of about 256,632 (314)
Analysis of the molecular subtypes of preoperative core needle biopsy and surgical specimens in invasive breast cancer [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Accurate molecular classification of breast core needle biopsy (CNB) tissue is important for determining neoadjuvant systemic therapies for invasive breast cancer.
Ye Sul Jeong +5 more
doaj +1 more source
Epigenetics and the Estrogen Receptor
Annals of the New York Academy of Sciences, 2006 Abstract: The position effect variegation in Drosophila and Schizosaccharomyces pombe, and higher‐order chromatin structure regulation in yeast, is orchestrated by modifier genes of the Su(var) group, (e.g., histone deacetylases ([HDACs]), protein phosphatases) and enhancer E(Var) group (e.g., ATP [adenosine 5′‐triphosphate]‐dependent nucleosome ...
Richard G. Pestell +5 more
openaire +3 more sources
Estrogen Receptors in the Male [PDF]
Archives of Andrology, 1981 Estrogens in the male are secreted by the testes and derived extragonadally from the aromatization of certain androgens. In some brain regions critical for the control of gonadotropin secretion and behavior, androgens may be aromatized to estrogens within the cells that are regulated. Estrogen may have other physiological roles on the testes to control
C. R. Clark, R. B. Dickson
openaire +3 more sources
Thyroid hormone receptors and ligand, tissue distribution and sexual behavior [PDF]
, 2018 The thyroid hormones (THs) triiodothyronine (T3) and tetraiodothyronine, or thyroxine (T4), not only dramatically impact on development and differentiation, but also on the sexual and reproductive function.
Carosa, E, Jannini, Ea, Lenzi, A
core +1 more source
Targeting mutant estrogen receptors
eLife, 2019 A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
Suzanne E Wardell +2 more
doaj +1 more source
Expression of female sex hormone receptors and its relation to clinicopathological characteristics and prognosis of lung adenocarcinoma [PDF]
Journal of Pathology and Translational Medicine, 2020 Background Adenocarcinoma (ADC) of the lung exhibits different clinicopathological characteristics in men and women. Recent studies have suggested that these differences originate from the expression of female sex hormone receptors in tumor cells.
Jin Hwan Lee +2 more
doaj +1 more source
Local estrogen formation and its regulation in endometriosis
Reproductive Medicine and Biology, 2019 Background It has been well established that endometriosis is an estrogen‐dependent disease. Although the exact pathogenesis of the disease is still unclear, it is known to be characterized by estrogen‐dependent growth and maintenance of the ectopic ...
Taisuke Mori +7 more
doaj +1 more source
The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]
, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel +8 more
core +3 more sources
The binding of estrogen and estrogen antagonists to the estrogen receptor
Archives of Biochemistry and Biophysics, 1992 The model of the estrogen receptor as a dimer of identical, interacting subunits and data obtained by Sasson and Notides (1988, Mol. Endocrinol. 2, 307-312) were used to find the standard free energy changes that describe the binding of estradiol and 4-hydroxytamoxifen to the estrogen receptor.
Shlomo Sasson +2 more
openaire +3 more sources
Molecular Imaging Provides Novel Insights on Estrogen Receptor Activity in Mouse Brain
Molecular Imaging, 2008 Estrogen receptors have long been known to be expressed in several brain areas in addition to those directly involved in the control of reproductive functions.
Alessia Stell +3 more
doaj +1 more source