Results 231 to 240 of about 299,300 (300)

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque. [PDF]

Front Immunol
Tolbert WD, Nhan PB, Conley HE, Ge X, Chandravanshi M, Lee M, Veilleux J, Korzeniowski M, Gottumukkala S, Ackerman ME, Pollara J, Pazgier M.   +11 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Antigen binding triggers long-range conformational changes in monoclonal antibodies. [PDF]

Front Immunol
Bianchi D, Saporiti S, Palinsky W, Ben Mariem O, Rossi M, Eberini I, Centola F.   +6 more
europepmc   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Psilocybin effects on brain functional connectivity: a systematic review of fMRI studies. [PDF]

Discov Ment Health
Farré-Colomés À, Rublinetska O, Soto-Angona Ó.   +2 more
europepmc   +1 more source

Impact of afucosylation strategy on antibody function: a comparative study of glycoengineered anti-CD20 antibodies Obinutuzumab and Obinutuzumab beta. [PDF]

MAbs
Shuang Q, Sun M, Lin G, Zhang L, Huang S, Shen Q, Jiang L, Yang L, Sun J, Chen H, Li F, Li J.   +11 more
europepmc   +1 more source

Apolipoprotein M: Structural insights, functional roles, and therapeutic approaches in vascular disease. [PDF]

J Biol Chem
Dorweiler TF, Hla T.
europepmc   +1 more source

Development of tCAP(N3): Affinity Peptide-Aided, pH-Triggered Strategy for Site-Specific Native IgG Modification. [PDF]

Chemistry
Kawakami H, Rafique A, Tsuda S, Nagashima A, Nohara Y, Dozono N, Sakamoto K, Masuda S, Kiyoshi M, Shibata H, Ishii-Watabe A, Yoshiya T, Ito Y.   +12 more
europepmc   +1 more source

<i>Orientia tsutsugamushi</i> binds to multiple C-type lectin receptors. [PDF]

Infect Immun
Hefter V, Mayer-Lambertz S, Orfanos Z, Mehl J, Lepenies B, Keller C.   +5 more
europepmc   +1 more source