Results 51 to 60 of about 159,070 (244)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors

mAbs
Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the clinic, but they
Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson   +4 more
doaj   +1 more source

The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses

Vaccines, 2018
Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer protection mediated by non-neutralizing anti-HA IgGs and to increase ...
Natalie K. Thulin, Taia T. Wang
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The Ligands for Human IgG and Their Effector Functions

Antibodies, 2019
Activation of the humoral immune system is initiated when antibodies recognize an antigen and trigger effector functions through the interaction with Fc engaging molecules.
Steven W. de Taeye, Theo Rispens, Gestur Vidarsson   +2 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance

Frontiers in Immunology
PurposePatients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure.
Bryan C. Remaily, Greg Young, Hannah Lathrop, Justin Thomas, Kyeongmin Kim, Trang T. Vu, Adeoluwa Adeluola, Camille Stanton, Gillian Mulcahy, Zhiliang Xie, Lauren Granchie, Yizhen Guo, Min Hai, Jessica Wedig, Maria Schmidt, Millennium Manna, Xiaokui Mo, Xiaokui Mo, Xiaokui Mo, Jeovanna Lowe, Jill A. Rafael-Fortney, Jill A. Rafael-Fortney, Edmund Folefac, Paul Gregorevic, Paul Gregorevic, Dwight H. Owen, Dwight H. Owen, Samuel K. Kulp, Latha P. Ganesan, Christopher C. Coss, Christopher C. Coss, Thomas A. Mace, Thomas A. Mace, Thomas A. Mace, Mitch A. Phelps, Mitch A. Phelps   +35 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV

Cell Reports
Summary: Antibodies binding cell-surface antigens to activate cellular immunity are an important mechanism of anti-viral protection, yet antibodies targeting cells infected by human cytomegalovirus (HCMV) exhibit limited efficacy.
Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash K. Mishra, George Delidakis, Kirsten Bentley, Lauren Kerr-Jones, Mica Cabrera, Truong Nguyen, Rebecca L. Göttler, Amjad Chowdhury, Philipp L. Kolb, Hartmut Hengel, George Georgiou, Jason S. McLellan, Richard J. Stanton, Annalee W. Nguyen, Jennifer A. Maynard   +19 more
doaj   +1 more source

PROTECTIVE ROLE OF ANTIBODIES IN TUBERCULOSIS AND HIV INFECTION

Медицина в Кузбассе, 2022
The review discusses the protective humoral mechanisms in tuberculosis and HIV infection. These include the immunoglobulin Fc receptor (Fc receptor) mediated antibody effector functions leading to pathogen clearance, antibody-dependent cellular ...
Нина Васильевна Мальцева
doaj