Results 251 to 260 of about 584,709 (292)

Evidence for M2 Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs. [PDF]

Invest Ophthalmol Vis Sci
Zhou H, Zhou G, Yang Q, Niu J, Wang R, Liu H, Hou S, Bi H, Liao X.   +8 more
europepmc   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner. [PDF]

Commun Biol
Löbbert A, Lorz N, Matthees ESF, Rößler P, Hoffmann C, Gossert AD.   +5 more
europepmc   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Association of Higher Levels of High‐Sensitivity C‐Reactive Protein With Future Development of Psoriatic Arthritis in Psoriasis: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective We aimed to assess whether high‐sensitivity C‐reactive protein (hsCRP) levels could predict the development of psoriatic arthritis (PsA) in patients with psoriasis. Methods We analyzed data from a prospective cohort of patients with psoriasis without PsA at enrollment.
Lihi Eder, Xianwei Li, Vinod Chandran, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman   +5 more
wiley   +1 more source

Naltrexone dose-selectively modulates goal-directed behavior and the hypothalamic proteome in rats. [PDF]

Pharmacol Rep
Malikowska-Racia N, Mielczarek P, Popik P.   +2 more
europepmc   +1 more source

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors. [PDF]

Nat Commun
Zhong Y, Tao H, Zhang Y, He B, Jiao H, Wang D, Teng M, Hu H, Guo Q, Tao Y.   +9 more
europepmc   +1 more source

Role of 5-HT_1A and 5-HT₇ Receptors in Memory Regulation and the Importance of Their Coexpression: A Systematic Review. [PDF]

Biomolecules
Briones-Aranda A, Flores-Durán D, Romero-Nava R, Corzo-Gómez JC, Cruz-Trujillo R, Toalá-Sepúlveda F, Del-Río-Navarro BE, Huang F.   +7 more
europepmc   +1 more source

Phylogenetic and Structural Insights into Melatonin Receptors in Plants: Case Study in <i>Capsicum chinense</i> Jacq. [PDF]

Plants (Basel)
Toledo-Castiñeira A, Valdés-Tresanco ME, Estrada-Tapia G, Monforte-González M, Martínez-Estévez M, Echevarría-Machado I.   +5 more
europepmc   +1 more source

LPAR6 Inhibits the Progression of Hepatocellular Carcinoma (HCC) by Suppressing the Nuclear Translocation of YAP/TAZ. [PDF]

Int J Mol Sci
Bao G, Zhai M, Yan Y, Wang Y, Damirin A.
europepmc   +1 more source