Results 251 to 260 of about 519,374 (316)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Structural insights into coffee bitter taste perception by TAS2R43 receptor. [PDF]

Nat Struct Mol Biol
Kim Y, Gumpper RH, Zhuang Y, Dror RO, Roth BL.   +4 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Indole Alkaloids as Biased Opioid Receptor Modulators. [PDF]

Pharmaceuticals (Basel)
Grundmann O, Henderson A.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

CXCR1 and CXCR2 display receptor bias for shared chemokine agonists. [PDF]

Mol Pharmacol
Jassal C, Strawn J, Walsh E, Rajarathnam K, Rajagopal S.   +4 more
europepmc   +1 more source

Approaches to deorphanize secretome: Classical, computational, and next generation strategies to reveal ligand-receptor networks. [PDF]

EXO
Han M, Perrimon N.
europepmc   +1 more source

Sustained CREB Phosphorylation Is Associated with Neuritogenic Prostanoid Signaling in NSC-34 Cells. [PDF]

Cells
Nagayama K, Nango H, Tsuruta K, Miyagishi H, Kosuge Y.   +4 more
europepmc   +1 more source

Structured water molecules drive activation and G protein selectivity in the GPR174 receptor. [PDF]

PLoS Biol
Dong YJ, Xi K, Zhang YZ, Xue JH, Shen DD, Zang SK, Zhao R, Qi H, Mao C, Wang WW, Zhang Y.   +10 more
europepmc   +1 more source