Results 111 to 120 of about 101,020 (265)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

GABA_A receptor dysfunction in autism spectrum disorder: molecular mechanisms and therapeutic opportunities. [PDF]

Front Pharmacol
Ragu Varman D, Sivamaruthi BS, Kesika P, Martínez-Torres A, Reyes-Haro D, Chaiyasut C.   +5 more
europepmc   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

GABA_A Receptor Modulators as Emerging Therapeutic Agents for Depressive Disorders. [PDF]

Drug Des Devel Ther
Guan BY, Li Y.
europepmc   +1 more source

GABA receptor [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

The endogenous cannabinoid system gates plasticity of tonic GABA inhibition. [PDF]

J Physiol
Colangeli R, Conti F.
europepmc   +1 more source

GABA RECEPTORS AND BENZODIAZEPINES

British Journal of Anaesthesia, 1993
openaire   +2 more sources

Direct modulation of human GABA-A α₁β₂γ₂ receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development. [PDF]

Front Neurosci
Mixcoha E, Flores-Zamora A, Hernández-Miramontes R, Hernández-Calderón JA, Martiñón S.   +4 more
europepmc   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source