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Curing the brain: in search for new astrocyte-specific therapies. [PDF]

open access: yesExp Mol Med
Verkhratsky A   +25 more
europepmc   +1 more source
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Astrocytic GABA receptors

Glia, 1994
AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
D D, Fraser   +2 more
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The Neurobiology of Gaba Receptors

2006
Gamma-aminobutyric acid (GABA) was first identified in 1950 (Roberts 1950; Awapara 1950) in brain extracts of various animal species and was subsequently found to be the principal inhibitory neurotransmitter in the central nervous system (CNS). GABA is synthesized as a result of decarboxylation of glutamic acid and is released by neurons into the ...
SANNA, ENRICO, FOLLESA, PAOLO, BIGGIO G.
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The ‘ABC’ of GABA receptors

Trends in Pharmacological Sciences, 2000
In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an early suggestion by Graham ...
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Occurrence of GABA and GABA receptors in human spermatozoa

Molecular Human Reproduction, 1998
Gamma-aminobutyric acid (GABA) concentrations in seminal plasma and washed spermatozoa from normal donors were assessed by a sensitive radioreceptor assay, and were detectable in both fractions. Specific binding of [3H]-muscimol was shown to be dependent on protein concentration, temperature and incubation time.
M N, Ritta, J C, Calamera, D E, Bas
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