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Phospholipids and the Gaba Receptor
1976Much interest has been focused on the role of phospholipids in the nervous system. For example, it has been suggested that these are intimately involved in the cholinergic receptor. De Robertis and his colleagues isolated proteolipids from mammalian nerve ending membranes and showed that they have a high affinity for d-tubocurarine and.
Cecilia T. Giambalvo +2 more
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Pharmacology of insect GABA receptors
Neurochemical Research, 1991A GABA-operated Cl- channel that is bicuculline-insensitive is abundant in the nervous tissue of cockroach, in housefly head preparations and thorax/abdomen preparations, and in similar preparations from several insect species. Bicuculline-insensitive GABA-operated Cl- channels, which are rare in vertebrates, possess sites of action of benzodiazepines,
Sattelle, David B. +3 more
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1990
Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Insights into the structure and pharmacology of GABA(A) receptors.
Future Medicinal Chemistry, 2010GABA is the major inhibitory neurotransmitter in the adult mammalian CNS. The ionotropic GABA type A receptors (GABA(A)Rs) belong to the Cys-loop family of receptors. Each member of the family is a large pentameric protein in which each subunit traverses
C. Carter, J. Kozuska, S. Dunn
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Neurochemical Research, 1978
Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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GABA Receptor molecules of insects
1993Receptors for 4-aminobutyric acid (GABA) have been identified in both central and peripheral nervous systems of several invertebrate phyla. To date, much of the information derived from physiological and biochemical studies on insect GABA receptors relates to GABA-gated chloride channels that show some similarities with vertebrate GABAA receptors. Like
Anthony, N. M. +2 more
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A diversity of GABA receptors in the retina
Seminars in Cell & Developmental Biology, 1998GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
Peter D. Lukasiewicz, Colleen R. Shields
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GABA and barbiturate receptors
Trends in Pharmacological Sciences, 1982Abstract Barbiturates potentiate GABA-mediated synaptic transmission in many areas of the CNS. Recent results from studies on the binding of radioactive GABA and phenobarbitone indicate that barbiturates act on a distinct class of receptors to decrease the rate of dissociation of GABA from certain receptors for this major inhibitory transmitter.
Max Willow, Graham A.R. Johnston
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Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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2007
γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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