Results 161 to 170 of about 62,827 (261)

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Unilateral Graves' Disease Developing During Treatment With Tirzepatide in a Patient With Diabetes: A Case Report. [PDF]

Case Rep Endocrinol
Deto Y, Hasegawa R, Ino S, Shibata S, Ohno K, Itoh T, Matsumoto T, Miki T.   +7 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Editorial: Advances in immunity and microbiome: exploring key interactions and innovations. [PDF]

Front Immunol
Pascual J, Martínez-Blanch JF, Amaro C, Roig FJ.   +3 more
europepmc   +1 more source

DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: G protein-coupled receptors in nutrient chemosensation and gastrointestinal hormone secretion1 [PDF]

Journal of Animal Science, 2013
openaire   +1 more source

Exploring Perspectives on Ozempic: A Netnographic Qualitative Evaluation of the Pro‐Eating Disorder Community on X (Formerly Twitter)

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are complex conditions with medical and psychosocial implications. Social media (SM) exposure has been associated with increased body image concerns and maladaptive eating behaviors. Pro‐eating disorder (pro‐ED) communities exist across SM platforms and often perpetuate ED‐related identities and behaviors.
Daisy Sun, Tovah Yanover, Helena Katona, Jennifer Couturier   +3 more
wiley   +1 more source

Oxytocin release patterns and effects, with a focus on touch, social interaction, and closeness. [PDF]

Front Psychol
Uvnäs-Moberg K, Petersson M.
europepmc   +1 more source

Prevalence of Eating Disorders and Disordered Eating Among School‐Based Students: A Rapid Review and Meta‐Analysis

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To synthesize recent global evidence on the prevalence of eating disorders and disordered eating among students in Grades 1–12. Method This rapid review and meta‐analysis followed Cochrane Rapid Review Methods and PRISMA guidelines.
Thi Ngoc Anh Hoang, Jessica Morgan, Ngoc Minh Pham, Sana Farzam, Chau Ho, Penelope Hasking   +5 more
wiley   +1 more source

Estrogen receptors and the NRF2 pathway: bridging hormonal regulation and stress response in the gut. [PDF]

Front Endocrinol (Lausanne)
Kopacz A, Tomaszewska Z, Piechota-Polanczyk A.   +2 more
europepmc   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source