Results 61 to 70 of about 60,589 (260)

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

The structure and function of taste G protein-coupled receptors and their implications in diseases

International Journal of Oral Science
Taste G protein-coupled receptors (GPCRs), including sweet (TAS1Rs) and bitter (TAS2Rs) taste receptors, are essential for detecting nutrients and avoiding toxins, influencing dietary behavior, metabolism, and overall health.
Ruohan Zhai, Xihao Yong, Peihua Jiang, Marco Tizzano, Zhenhua Shao, Wei Yan, Xin Zheng   +6 more
doaj   +1 more source

Metabolic Regulation by the Hypothalamic Neuropeptide, Gonadotropin-Inhibitory Hormone at Both the Central and Peripheral Levels

Cells
Gonadotropin-inhibitory hormone (GnIH) is well-established as a negative regulator of reproductive physiology and behavior across vertebrates, acting on the hypothalamic–pituitary–gonadal (HPG) axis; however, recent data have also demonstrated its ...
You Lee Son, Simone L. Meddle, Yasuko Tobari   +2 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Insulin-like Growth Factors (IGFs) and their binding proteins (IGFBPs) as biomarkers of catabolism [PDF]

Journal of Medical Biochemistry, 2007
The life of an organism depends on its capacity to maintain equilibrium Disease induces acute adaptive responses specific to the stimulus and the organism achieves stability through change.
Nedić Olgica, Nikolić-Judith Anna, Malenković Vesna, Baričević-Jones Ivona   +3 more
doaj  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones

FEBS Open Bio
Food‐derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal transduction circuit of the brain–gut axis has been analyzed in animals; however, species ...
Yuka Akagi, Yuzo Takayama, Yuma Nihashi, Azusa Yamashita, Risa Yoshida, Yasuhisa Miyamoto, Yasuyuki S. Kida   +6 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source