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Recent Developments in Ghrelin Receptor Ligands
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aline, Moulin +3 more
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Ghrelin Receptors and Epilepsy
2014Epilepsy is a neurological disorder that affects more than 50 million people worldwide. One-third of all epilepsy patients do not respond to the antiepileptic medications that are currently available. As such, there is a great need for new, more effective drugs for the treatment of epilepsy.
Portelli, Jeanelle +3 more
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Changes in ghrelin and ghrelin receptor expression according to feeding status
NeuroReport, 2003Ghrelin, a newly identified gut hormone, has been implicated in the regulation of food intake and energy homeostasis. This study was undertaken to investigate changes in expression levels of stomach ghrelin as well as of ghrelin receptor in the hypothalamus and pituitary glands according to feeding state.
Min-Seon, Kim +7 more
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Ghrelin Receptor Modulators and Their Therapeutic Potential
Future Medicinal Chemistry, 2009Ghrelin is a peptide produced predominantly in the stomach and intestines, and is a natural growth hormone (GH) secretagogue-receptor ligand. It is able to stimulate GH release, but it also exhibits an important role in conditions related to processes regulating nutrition, body composition and growth, and heart, liver, thyroid or kidney dysfunction ...
COSTANTINO, Luca, D. Barlocco
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Diminished Endometrial Expression of Ghrelin and Ghrelin Receptor Contributes to Infertility
Reproductive Sciences, 2010The objectives were to investigate the presence, distribution and sex steroid hormone regulation of ghrelin and its receptor, growth hormone secretagogue receptor (GHSR), in human endometrium in relation to endometrial receptivity and fertility. Endometrial biopsies were obtained from women with unexplained infertility and healthy fertile volunteers ...
Lusine, Aghajanova +4 more
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Ghrelin and ghrelin receptor inhibitors: agents in the treatment of obesity
Expert Opinion on Therapeutic Targets, 2008Current medical treatment of obesity is highly ineffective. Soon after its discovery as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R), ghrelin was shown to stimulate food intake (including in humans) and promote body weight gain and adipogenesis.This review discusses the role of the ghrelin/GHS-R pathway in energy ...
João-Bruno, Soares +2 more
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Traceable Peptidic Ligands that Target Ghrelin Receptors
Current Protein & Peptide Science, 2020: Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide’s signaling pathway.
Mengjie, Liu +2 more
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Ghrelin Receptor Mutations and Human Obesity
2016Growth hormone secretagogue receptor (GHSR) was originally identified as an orphan receptor in porcine and rat anterior pituitary membranes. In 1999, GHSR was deorphanized and shown to be a receptor for ghrelin, a peptide hormone secreted from the stomach. Therefore, GHSR is also called ghrelin receptor.
W, Wang, Y-X, Tao
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Central Functions of the Ghrelin Receptor
2014The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others.
Portelli, Jeanelle, Smolders, Ilse
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