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Cognitive enhancing effects of ghrelin receptor agonists
Psychopharmacology, 2009Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, has been shown to play a role in multiple physiological processes including appetite regulation, metabolism and, more recently, dendritic spine architecture, long-term potentiation and cognition.The objective of this study was to determine the effects of two structurally non ...
Atcha, Z +7 more
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Cell Biology of the Ghrelin Receptor
Journal of Neuroendocrinology, 2005AbstractGhrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS‐R1a), a G‐protein coupled receptor mainly expressed in the pituitary and hypothalamus.
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Chapter 9. Ghrelin receptor modulators
2003Publisher Summary This chapter focuses on ghrelin receptor modulators. Ghrelin is a 28 amino acid peptide produced predominantly by the stomach and intestines. It has recently been identified as an endogenous ligand for the growth hormone secretagogue receptor, 1a (GHS-R1a).
Jeffrey A. Dodge, Mark L. Heiman
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Neuropharmacology, 2010
Obesity has reached epidemic proportions not only in Western societies but also in the developing world. Current pharmacological treatments for obesity are either lacking in efficacy and/or are burdened with adverse side effects. Thus, novel strategies are required.
Harriët, Schellekens +2 more
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Obesity has reached epidemic proportions not only in Western societies but also in the developing world. Current pharmacological treatments for obesity are either lacking in efficacy and/or are burdened with adverse side effects. Thus, novel strategies are required.
Harriët, Schellekens +2 more
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Ghrelin receptor modulators: a patent review (2011 – 2014)
Expert Opinion on Therapeutic Patents, 2014Over the past 3 years, several patents appeared dealing with the discovery of compounds able to modulate ghrelin actions: agonists for the treatment of cachexia, as diagnostic agents for GH deficiency or for the increase in gastrointestinal motility, antagonists and inverse agonists as anorexigenic agents for the treatment of obesity and type 2 ...
COSTANTINO, Luca, Barlocco D.
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Cellular Signalling, 2007
The dimerization properties of the ghrelin receptor (GRLN-R) and its non-signalling, naturally occurring, truncated splice variant (GHS-R1b) have been investigated in human embryonic kidney 293 cells heterologously expressing these proteins. Using the techniques of bioluminescence resonance energy transfer and co-immunoprecipitation, we detected the ...
Chu, Kit Man +6 more
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The dimerization properties of the ghrelin receptor (GRLN-R) and its non-signalling, naturally occurring, truncated splice variant (GHS-R1b) have been investigated in human embryonic kidney 293 cells heterologously expressing these proteins. Using the techniques of bioluminescence resonance energy transfer and co-immunoprecipitation, we detected the ...
Chu, Kit Man +6 more
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Thermogenic Characterization of Ghrelin Receptor Null Mice
2012Ghrelin is the only known circulating orexigenic hormone that increases food intake and promotes adiposity, and these physiological functions of ghrelin are mediated through its receptor growth hormone secretagogue receptor (GHS-R). Ghrelin/GHS-R signaling plays a crucial role in energy homeostasis.
Ligen, Lin, Yuxiang, Sun
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Ala-scan of ghrelin (1–14): interaction with the recombinant human ghrelin receptor
Peptides, 2004Ghrelin, a 28 residues acylated peptide, is the natural ligand of the growth-hormone secretagogue receptor (GHS-R), which also interacts with small synthetic peptides. We investigated the importance of each of the first 14 N-terminal residues by Ala replacement (Ala-scan) and also of the N-terminal positive charge, on the recombinant GHS-R expressed in
Van Craenenbroeck, Mélanie +4 more
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Central Ghrelin Receptors and Food Intake
2014Feeding is a vital function that provides nutritional and energy metabolism needs for animals. To ensure feeding, mammalian brains possess several interrelated neuronal systems that regulate different aspects of feeding behaviors. These neuronal circuits controlling food intake are strongly regulated by peripheral signals that contribute to the fine ...
Mario Perello, Jesica Raingo
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Constitutive Activity of the Ghrelin Receptor
2014Cloning and characterization of the ghrelin receptor as a 7-transmembrane (7TM), G-protein-coupled receptor (GPCR) was first reported by Howard and his co-workers (1996). The ghrelin receptor was initially described as a growth hormone secretagogue receptor since (GHSR) this was the most well-established physiological function at that time. The natural
Jacek Mokrosiński +2 more
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