Results 61 to 70 of about 2,692,169 (258)

Relationship of Ghrelin and Ghrelin Receptor Polymorphisms with Type 2 Diabetes

, 2022
There is compelling evidence that the gastric peptide ghrelin and its growth hormone secretagogue G protein-coupled receptor play an important role in glucose metabolism and energy homeostasis. Therefore, these genes carrying susceptibility alleles for Type 2 diabetes are considered as potential candidates.A case-control cross-sectional association ...
Özkahraman, Didem, Selçuk, Esma, Şahin Calapoğlu, Nilüfer, Calapoğlu, Mustafa, Şahin, Uğur   +4 more
openaire   +3 more sources

Impact of bariatric surgery on alcohol‐use disorder and alcohol‐related liver disease: A retrospective study

Addiction, EarlyView.
Abstract Background and aims Increased risk of alcohol dependence is recognised following bariatric surgery. Modified gastrointestinal anatomy and neurohormonal profiles lead to altered alcohol metabolism, peak blood alcohol concentrations and enhanced reward circuits and cravings.
Thomas J. Williams, Andrew J. Palmer, Jason P. Connor, Gerald Holtmann, Paul J. Clark   +4 more
wiley   +1 more source

Role of SST, CORT and Ghrelin and its receptors at the endocrine pancreas.

Frontiers in Endocrinology, 2012
Somatostatin (SST), cortistatin (CORT), and its receptors (sst1-5), and ghrelin and its receptors (GHS-R) are two highly interrelated neuropeptide systems with a broad range of overlapping biological actions at central, cardiovascular and immune levels ...
Belen eChanclón, Antonio J eMartínez-Fuentes, Francisco eGracia-Navarro   +2 more
doaj   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

eLife, 2015
Feeding behavior rarely occurs in direct response to metabolic deficit, yet the overwhelming majority of research on the biology of food intake control has focused on basic metabolic and homeostatic neurobiological substrates.
Ted M Hsu, Joel D Hahn, Vaibhav R Konanur, Emily E Noble, Andrea N Suarez, Jessica Thai, Emily M Nakamoto, Scott E Kanoski   +7 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Brazilian Oral Research, 2019
: Recently, it has been suggested that the anti-inflammatory hormone ghrelin (GHRL) and its receptor GHS-R may play a pivotal role in periodontal health and diseases. However, their exact regulation and effects in periodontitis are not known.
Marjan Nokhbehsaim, Andressa Vilas Boas Nogueira, Svenja Memmert, Anna Damanaki, Sigrun Eick, Joni Augusto Cirelli, James Deschner   +6 more
doaj   +1 more source

The amygdala as a neurobiological target for ghrelin in rats: neuroanatomical, electrophysiological and behavioral evidence. [PDF]

PLoS ONE, 2012
Here, we sought to demonstrate that the orexigenic circulating hormone, ghrelin, is able to exert neurobiological effects (including those linked to feeding control) at the level of the amygdala, involving neuroanatomical, electrophysiological and ...
Mayte Alvarez-Crespo, Karolina P Skibicka, Imre Farkas, Csilla S Molnár, Emil Egecioglu, Erik Hrabovszky, Zsolt Liposits, Suzanne L Dickson   +7 more
doaj   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications

Frontiers in Endocrinology, 2013
Somatostatin is an important modulator of neurotransmission in the central nervous system and acts as a potent inhibitor of hormone and exocrine secretion and regulator of cell proliferation in the periphery.
Andreas eStengel, Yvette F. Taché
doaj   +1 more source