Results 191 to 200 of about 74,867 (310)

Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models

Obesity, EarlyView.
ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand, Camille Le Cudennec, Estelle Grasset, Natalia Breyner, Claire Bigot, Pierre Dillard, Thierry Sulpice   +6 more
wiley   +1 more source

The expanding landscape of the glucagon signaling network: mechanisms and outcomes.

Endocrinology
Foollee A, Wu Y, Rusu PM, Rose AJ.
europepmc   +1 more source

Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders. [PDF]

Diabetes Metab Syndr Obes
Qiao Y, Zhou F, Mao T, Gao L.
europepmc   +1 more source

Twenty‐Four Month Outcomes From a Real‐World Telehealth Obesity Treatment Clinic Using Obesity Medications

Obesity, EarlyView.
ABSTRACT Objective Antiobesity medications (AOMs) are indicated for long‐term use; however, evidence of their real‐world long‐term efficacy is limited. This study describes clinical outcomes from 18‐ and 24‐month use of AOMs in a telemedicine weight management clinic.
Kathleen R. Ruddiman, Young‐Rock Hong, Jamy Ard, Rebecca Jones, Adam Medcalf, Gary D. Foster, Jamil Alkhaddo, Michelle Cardel   +7 more
wiley   +1 more source

GLP-1 Receptor Agonists and Blood Pressure: A State-of-the-Art Review of Mechanisms, Evidence, and Clinical Implications. [PDF]

Am J Hypertens
Moiz A, Zolotarova T, Filion KB, Eisenberg MJ.   +3 more
europepmc   +1 more source

Glucagon Receptor Binding [PDF]

, 2020
openaire   +1 more source

Weight Loss With GLP‐1 Agonists in Nondiabetic Adults: Systematic Review and Network Meta‐Analysis

Obesity, EarlyView.
ABSTRACT Objective Two glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) (semaglutide and liraglutide) and one dual agonist (tirzepatide) are FDA‐approved for weight loss in adults with obesity without type 2 diabetes mellitus. This systematic review and network meta‐analysis aims to compare the efficacy of these agents against each other.
Michael Lim, Pooja Gokhale, Akwasi Akosah, Lorenzo Villa‐Zapata   +3 more
wiley   +1 more source

Translocation intermediates on the import pathway of proteins into mitochondria [PDF]

, 1987
Hartl, Franz-Ulrich, Neupert, Walter, Pfanner, Nikolaus   +2 more
core   +1 more source

The NeuroImmunoEndocrine Circuit of Umami Peptides: A Systems Biology Approach. [PDF]

Nutrients
Hemmati S, Mohagheghzadeh A.
europepmc   +1 more source

Prevalence of Pre‐Clinical Obesity Among US Adults Receiving Medical and Surgical Obesity Treatment

Obesity, EarlyView.
ABSTRACT Objective We sought to determine how the proportion of adults historically receiving obesity interventions would be classified under the recently proposed “pre‐clinical” and “clinical” obesity classifications and the impact of this change on safety and outcomes.
Jason M. Samuels, Emma Holler, Matthew D. Spann, C. Joe Northup, Tarik K. Yuce   +4 more
wiley   +1 more source