Results 211 to 220 of about 74,867 (310)
Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source
Paracrine Hormonal Signals From Islet α-Cells Regulate Microtubule Dynamics in β-Cells to Promote Insulin Secretion in Mouse and Human Islets. [PDF]
DiabetesHo KH +9 more
europepmc +1 more source
Living Well With Type 1 Diabetes in Middle School: A Student‐Centered Perspective
Psychology in the Schools, EarlyView.ABSTRACT Type 1 diabetes (T1D) is among the most common chronic illnesses affecting children and adolescents, meaning that all schools regularly include students with T1D. Supporting their well‐being requires understanding how they experience middle school to address their specific needs.
Isabelle Joing +4 more
wiley +1 more source
Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues. [PDF]
Physiol RepHakizimana JC, Olubiyi MV, Alagbonsi AI.
europepmc +1 more source
PROTEOMICS, EarlyView.ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam +4 more
wiley +1 more source
Portal Hypertension &Cirrhosis, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a chronic liver disease. Research into a feasible, rapid, and effective assessment method is crucial for evaluating the therapeutic effects of semaglutide in MASLD. This prospective study utilized ultrasound‐derived fat fraction measurement and fat‐to‐muscle ratio to evaluate hepatic ...
Yunlin Huang +10 more
wiley +1 more source
Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in <i>Drosophila</i>. [PDF]
ElifeZhao Y, Duan J, van de Leemput J, Han Z.
europepmc +1 more source
From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies
Portal Hypertension &Cirrhosis, EarlyView.This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu +5 more
wiley +1 more source
Glucagon-like Peptide-1 and Dual GIP/GLP-1 Receptor Agonists in Brain: Exploring the Expanding Role and Safety in Neuropsychiatry. [PDF]
Int J Mol SciTudosie AC, Marin LM, Popa SG, Golli AL.
europepmc +1 more source
When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble
Portal Hypertension &Cirrhosis, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen +5 more
wiley +1 more source