Results 121 to 130 of about 230,640 (243)

Tailored Fluorescent Metal–Organic Frameworks Hybrid Membrane Sensor Arrays: Simultaneous and Selective Quantification of Multiple Antibiotics

Advanced Science, EarlyView.
A filterable paper‐based fluorescent metal–organic frameworks (MOFs) sensor array is developed for one‐to‐one recognition and simultaneous quantification of multiple antibiotics. Three representative MOFs are strategically designed to exhibit exceptional affinity and specificity for the target antibiotic.
Tongtong Ma, Qiao Huang, Lei Yuan, Shugang Yan, Yalin Mo, Yibin Ying, Yingchun Fu, Jinming Pan   +7 more
wiley   +1 more source

Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in <i>Xenopus</i> oocytes. [PDF]

Comput Struct Biotechnol J
Eom S, Pyeon M, Moon M, Yun J, Yang J, Yun J, Yeom HD, Lee MH, Lee G, Lee JH.   +9 more
europepmc   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

The GluN3-containing NMDA receptors. [PDF]

Channels (Austin)
Xiong K, Lou S, Lian Z, Wu Y, Kou Z.
europepmc   +1 more source

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

Advanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia, Fuwen Wang, Xiaoyu Luo, Shuang Li, Yang Lyu, Yining Zheng, Zhijie Ma, Kaixing Qu, Rende Song, Jianyong Liu, Jicai Zhang, Basang Wangdui, Basang Zhuzha, Suolang Quji, Li Zhao, Silang Wangmu, Ciren Luobu, Nima Cangjue, Danzeng Luosang, Suolang Sizhu, Haijian Cheng, Ruizhe Li, Zhipeng Wu, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Luohao Xu, Haifei Hu, WaiYee Low, Zhuqing Zheng, Yu Wang, Yuanpeng Gao, Lu Deng, Johannes A. Lenstra, Jianlin Han, Xueyi Yang, Wenfa Lyu, Bizhi Huang, Chuzhao Lei, Ningbo Chen   +39 more
wiley   +1 more source

Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathway. [PDF]

JCI Insight
Zhang Z, Ye WW, Piro AL, Wang DS, Untereiner A, Lyons SA, Bhattacharjee A, Singh I, Beaudry JL, Orser BA, Dai FF, Wheeler MB.   +11 more
europepmc   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Molecular correlates of glycine receptor activity in human β cells. [PDF]

Mol Metab
Schukarucha Gomes A, Ellis CE, Spigelman AF, Dos Santos T, Maghera J, Suzuki K, MacDonald PE.   +6 more
europepmc   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Glutamate-Based Therapeutic Strategies for Schizophrenia: Emerging Approaches Beyond Dopamine. [PDF]

Int J Mol Sci
Fadgyas-Stanculete M, Capatina OO.
europepmc   +1 more source