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Receptors for fibroblast growth factors
Immunology & Cell Biology, 1995SummaryThe recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors (FGFR) has led to an intensification of study of this field. It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors (FGF) must bind in order to successfully activate the ...
J C, Coutts, J T, Gallagher
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Hematopoietic growth factor receptors
Cytotechnology, 1989The formation of the cellular constituents of the blood is regulated by a series of endogenous polypeptides with largely paracrine function. A number of these hematopoietic growth factors (HGF's), which include colony stimulating factors, interleukins, and erythropoietin, have been purified to homogeneity and cloned, which in turn has led to extensive ...
J H, Shieh, M A, Moore
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Journal of Pharmacology and Experimental Therapeutics, 2000
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the treatment of chronic myelogenous leukemia.
E. Buchdunger +6 more
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STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the treatment of chronic myelogenous leukemia.
E. Buchdunger +6 more
semanticscholar +1 more source
Epidermal growth factor receptors
Molecular and Cellular Biochemistry, 1981EGF-Rs are cell membrane glycoproteins of wide distribution. They have not yet been fully characterized or purified but are probably molecules of 170-190,000 mol. wt. in most cells. The growth factor EGF binds and will saturate cell surface receptors with a KA of about 5 X 10(9) M-1 although a receptor class with an affinity in excess of 10(10) M-1 has
E D, Adamson, A R, Rees
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Keratinocyte Growth Factor Receptors
Dermatologic Clinics, 2007Modulation of the number of functional growth factor receptors on the epithelial cell surface that is exposed to the action of cognate ligands represents a key strategy in cellular physiology to regulate the proliferation rate and the differentiation process. The keratinocyte growth factor receptor (KGFR) and the epidermal growth factor receptor (EGFR),
Vincenzo de Giorgi +4 more
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Growth factor receptors and their ligands
Journal of Neuro-Oncology, 1994The understanding of the signal transduction cascade involving growth factors and their receptors is one major key for diagnostic and therapeutic improvements in human neoplasms. Using receptor autoradiography, an inverse relationship for the incidence of somatostatin receptors (SSR) and epidermal growth factor receptors (EGFR) was found in gliomas [1].
Eppenberger U, Mueller H
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British Medical Bulletin, 1989
The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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The initial interaction of growth factors with their target cells is mediated by specific high affinity cell surface receptors. The structural and functional diversity found in growth factors is more limited at the receptor level where receptors for structurally and functionally distinct factors seem to share structural motifs and employ a restricted ...
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Endocytosis of growth factor receptors
BioEssays, 1993AbstractBinding of a growth factor (GF) to its specific receptor on the cell surface causes the initiation of a signal transduction cascade which eventually results in mitosis. GF:receptor complexes are removed from the cell surface via receptorâmediated endocytosis, a process which involves clathrinâcoated pits.
A, Sorkin, C M, Waters
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Hematopoietic growth factor receptors
The International Journal of Cell Cloning, 1991The molecular cloning for most of the hematopoietic growth factor receptors has been achieved over the past few years and revealed that they can by assigned to two discrete receptor families, namely the hematopoietic growth factor superfamily (HRS) and the receptor tyrosine kinase family (RTK).
M F, Brizzi, G C, Avanzi, L, Pegoraro
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1991
Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
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Proliferation of normal cells is regulated through the complex interaction of each cell with neighboring homologous and heterologous cells and extracellular tissue components forming its microenvironment. In addition to the cell-cell and cell-extracellular matrix contact, the proliferation of cells is regulated by a variety of soluble growth factors ...
openaire +2 more sources